Song Science publication celebrated

Fellow authors and colleagues gathered together last month to celebrate Long-Sheng Song, MD, Professor in Cardiovascular Medicine, and his study’s publication in Science’s online platform. Dr. Song’s publication revealed that the fragmentation of the protein junctophilin-2 can regulate genes and prevent heart failure following cardiovascular stress. “We have long known that this protein is a […]

Internal Medicine Grand Rounds in 2018: Variety and Depth

As medical education has moved from standing bedside with Sir William Osler into the auditorium and all the way to recorded presentations accessible from a device that fits inside your pocket, the concept of Grand Rounds has adapted. Though many institutions reportedly have reduced the primacy of the patient at the center, Internal Medicine at […]

A Year in Rearview

It was an honor to deliver my third annual State of the Department address last week. One hour is not nearly enough time to detail all the incredible activity that occurs over a twelve-month period in our department. In every component of our tripartite mission, the department ends 2018 on stronger footing than when the […]

Iowa receives continued CFF accreditation

Providers at University of Iowa Health Care learned this week that they have earned continued accreditation from the Cystic Fibrosis Foundation (CFF). The CFF establishes a standard of care based on guidelines developed with leading experts and based on peer-reviewed evidence and research. By adhering to those guidelines, establishing meaningful quality improvement, and undergoing a […]

Iowa results part of NEJM publication

A recent issue of the New England Journal of Medicine features the results of a multi-site clinical trial in which Dr. Mo Milhem and the University of Iowa’s Holden Comprehensive Cancer Center participated. Sorafenib, a kinase inhibitor primarily used to treat renal, hepatic, and thyroid carcinomas, was used against a placebo in a double-blind, phase […]

Nayak abstract featured in Best of ASH

For the second year in a row, Manasa Nayak, MsC, PhD, received an Abstract Achievement Award at the American Society of Hematology (ASH) annual meeting for a presentation submission. However, at this year’s ASH meeting—its 60th—in San Diego earlier this month, Dr. Nayak’s abstract earned an additional prize. His abstract, “Manipulating Plasticity by Targeting Pyruvate […]

The clinical promise of immunotherapy in triple-negative breast cancer

Article: The clinical promise of immunotherapy in triple-negative breast cancer Authors: Praveen Vikas, Nicholas Borcherding, Weizhou Zhang Journal: Cancer Management and Research 2018(10):6823—6833 Abstract: Triple-negative breast cancer (TNBC) is a heterogeneous disease with poorer outcomes compared to other breast cancer subtypes. Contributing to the worse prognosis in TNBC is the higher rates of relapse and […]

Foundations & Innovations 2018

In 2017, the Department of Internal Medicine produced its first print publication in many years, gathering an overview of the remarkable work taking place here. We asked each Division Director and our Residency Program Director to describe in their own words just a few of their recent successes and where they were headed next. We […]

HOBMT Leadership Change

I am pleased to announce that we have implemented a new leadership structure for the Division of Hematology, Oncology, and Blood & Marrow Transplantation (HOBMT). The missions of the division have been divided operationally into a Section of Oncology led by Mohammed Milhem, MBBS, and a Section of Hematology led by Steven Lentz, MD, PhD. […]

Disruption of Cardiac Med1 Inhibits RNA Polymerase-II Promoter Occupancy and Promotes Chromatin Remodeling

Article: Disruption of Cardiac Med1 Inhibits RNA Polymerase-II Promoter Occupancy and Promotes Chromatin Remodeling Authors: Duane D Hall, Kathryn M Spitler, and Chad E Grueter Journal: Am J Physiol Heart Circ Physiol. 2018 Nov 21 Abstract: The Mediator co-activator complex directs gene specific expression by binding distal enhancer-bound transcription factors through its Med1 subunit while […]