Phase I clinical trial group finds efficiencies, increases

Opening any clinical trial requires the satisfaction of many regulatory requirements for very good reasons. Scores of people review applications, confer in committees, weigh risks and benefits, all to make sure that the investigator has patient safety as their guide. This process is important, but it can also be lengthy and overlong delays can doom a trial before it can even […]

Dodd expands MPNST research with new DOD grant

Rebecca Dodd, PhD, assistant professor in Hematology, Oncology, and Blood and Marrow Transplantation, received a three-year $811,125 grant from the US Department of Defense (DOD). Titled “Targeting a pro-tumorigenic immunosuppressive loop in MPNST,” Dodd’s project will examine the processes behind Malignant Peripheral Nerve Sheath Tumor (MPNST) development. MPNSTs are sarcomas that occur in 8-13% of […]

StARR grant offers Peds, IntMed residents research opportunities

Training programs at Iowa have always promised flexibility, offering opportunities to tailor specifics in order to meet long-term career goals. Now, with the receipt of a four-year, $1.3M R38 grant from the NIH’s National Heart, Lung and Blood Institute (NHLBI), trainees in the Departments of Internal Medicine and of Pediatrics have access to a new […]

Rosen to investigate mechanisms of pulmonary fibrosis on collaborative U01

Bradley H. Rosen, DO, assistant professor in Pulmonary, Critical Care, and Occupational Medicine is the principal investigator on a four-year, $245K collaborative U01 subaward with the NIH’s National Heart, Lung, and Blood Institute. Rosen will lead the University of Iowa’s effort to understand the pathobiological mechanisms that lead to idiopathic pulmonary fibrosis (IPF). IPF is […]

Teamwork, Swiss cheese prove the difference in COVID-19 prevention

Frequent, universal COVID-19 testing has been one of the chief preventive methods used in long-term care facilities (LTCs). Although only 8% of COVID-19 cases occur in LTCs, these cases have accounted for 40% of all reported COVID-related deaths. Many facilities have employed the Center for Medicare and Medicaid Services’ (CMS) recommendation to frequently test their employees […]

Dayal to examine COVID-19 clotting

Sanjana Dayal, PhD, assistant professor in Hematology, Oncology and Blood & Marrow Transplantation, received a $50,000 COVID-19 Pilot Grant from the Roy J. Carver Charitable Trust. This funding will allow Dayal to examine the mechanisms of hypercoagulation in COVID-19 mouse models.  Hypercoagulation, also known as excessive blood clotting, tends to occur in COVID-19 patients and often […]

Goto receives K08 to develop a “smart antibiogram”

Bacterial infections that develop resistance to drugs affect at least 2.8 million Americans each year. Gram-negative rod (GNR) infections especially have high and emerging resistance rates and pose a large threat, considering the lack of new antimicrobial medicine. GNR pathogens can cause a wide variety of infections, such as urinary tract infections, pneumonia, or intraabdominal […]

Wei receives $2.3M R01

Shunguang Wei, PhD, assistant professor in Cardiovascular Medicine, received a four-year, $2.3M R01 grant from the NIH’s National Heart, Lung, and Blood Institute (NHLBI). Wei’s project will investigate the role of cytokine interleukin (IL-17A) in brain inflammation and sympathetic nervous system activation in a rat model of heart failure-induced by myocardial infarction. IL-17A is an […]

2021 Research Seminar Series Schedule Announced

The Internal Medicine Research Seminar Series, enters its fifth year providing a unique forum to showcase the broad array of discovery being conducted within the department, as well as invited presenters from across the country. The typical format is comprised of two presenters who will each describe their individual work for 20 minutes and reserve […]

Decreasing ceramides reduced obesity, insulin resistance in mice

Thermogenic adipocytes are specialized cells capable of converting chemical energy into heat and regulating body temperature. However, aging and weight gain can deplete thermogenic adipocytes and increase insulin resistance. Bhagirath Chaurasia, PhD, assistant professor in Endocrinology and Metabolism, aimed to determine the mechanisms behind this correlation in a study recently published in Molecular Metabolism. “Thermogenic adipocyte quantity […]