Pereira investigates brown fat cell role in combating obesity

Obesity and obesity-related diabetes and heart disease affect nearly half of adults in the United States. One potential solution to alleviate its prevalence may lie in finding ways to increase metabolism. With a five-year $1.93M R01, Renata Pereira, PhD, research assistant professor in Endocrinology and Metabolism, and a team of researchers plan to investigate methods […]

Clinicians develop model to calculate patient risk for NAFLD decompensation

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide and is associated with conditions such as obesity and metabolic syndrome, which can lead to diabetes, stroke, and heart disease. Although common, identifying people who could be at risk for NAFLD decompensation can be challenging for physicians. “We needed a way […]

Khataei deepens understanding of exercise’s effects

Tahsin Khataei, PhD, research assistant in the lab of Christopher Benson, MD, says that although the mental and physical health benefits of routine exercise is widely known, many do not participate in regular exercise regimens. “One reason for this is that exercise, especially high-intensity exercise, is often accompanied by muscle pain and fatigue—felt to be […]

Clinical trials in cancer at Iowa barely lose a step

Last week, the American Society of Clinical Oncology (ASCO) released a special report titled “A Guide to Cancer Care Delivery During the COVID-19 Pandemic.” It details an approach for oncologists and other care providers to ensure their own safety and that of those they treat, given the higher likelihood of a patient’s immuno-compromised status.  For […]

Grumbach collaboration to examine impact of radiation on blood vessels

Isabella Grumbach, MD, PhD, professor in Cardiovascular Medicine, and Randy Kardon, MD, PhD, professor of Ophthalmology and Visual Sciences, received a five-year, R01 grant for $2.5 million from the National Institutes of Health. The duo will study the effects of radiation therapy on small blood vessels, also known as microvessels, in cancer survivors. Every year, […]

Dhanesha presents in AHA finals competition

Nirav Dhanesha, PhD, research assistant professor in Hematology, Oncology and Blood & Marrow Transplantation, qualified as a finalist for the American Heart Association’s (AHA’s) Kenneth M. Brinkhous Early Career Investigator Prize in Thrombosis. As one of the four finalists, the AHA recognized Dhanesha, a member of the Chauhan Lab, as one of the young investigators […]

Sabharwal finds sexual differences in murine cardiomyopathies

Rasna Sabharwal, PhD, research assistant professor in Cardiovascular Medicine, received a four-year, $2.1M R01 from the NIH for her project “Stress-induced cardiovascular dysfunction in dilated cardiomyopathy.” With this funding, Sabharwal will investigate the central mechanisms and neural circuitry of emotional stress-mediated sudden death in dilated cardiomyopathy. With more than 200,000 cases a year in the […]

Cho focuses on keeping influenza immune response safe

Josalyn Cho, MD, assistant professor in Pulmonary, Critical Care and Occupational Medicine, earned a five-year, $2.6 million R01 from the NIH to investigate an immune regulatory protein, T cell immunoglobulin and mucin domain 3 (Tim3), and its impact on influenza infection in the lungs. “During influenza infection, the immune response must be tightly regulated to […]

London leads team studying cancer treatment’s cardiac impact

Barry London, MD, PhD, professor and director of the Division of Cardiovascular Medicine, received a four-year, $1.8 million R01 grant from the NIH to investigate the effects of radiation on the heart. Treatment for lung and esophageal cancer exposes the heart to radiation, which can eventually cause abnormal heart rhythms and sudden death. “We will use […]

A day in the life . . .

Models are by their nature subject to constant revision. Two weeks ago, we believed we would now be in the peak of demand on University of Iowa Health Care resources as a result of the COVID-19 pandemic. Recent well-publicized outbreaks in Iowa and other factors have now pushed our peak to around May 8. That […]