Desensitization strategies: is it worth it?

Article: Desensitization strategies: is it worth it? Authors: Sarat Kuppachi, David A. Axelrod Journal: doi: 10.1111/TRI.13532 Abstract: Preformed donor specific antibodies limit access to transplantation for thousands of renal transplant patients. While kidney paired donation offers the best strategy for patients with a living donor, for very highly sensitized patients and those without living donors, […]

Inpatient Fluoroquinolone Stewardship Improves the Quantity and Quality of Fluoroquinolone-prescribing at Hospital Discharge: A Retrospective Analysis among 122 Veterans Health Administration Hospitals

Article: Inpatient Fluoroquinolone Stewardship Improves the Quantity and Quality of Fluoroquinolone-prescribing at Hospital Discharge: A Retrospective Analysis among 122 Veterans Health Administration Hospitals Authors: Hiroyuki Suzuki, MD, Eli N Perencevich, MD, MS, Bruce Alexander, PharmD, Brice E Beck, MA, Michihiko Goto, MD, MSCI, Brian C Lund, PharmD, Rajeshwari Nair, MBBS, PhD, Daniel J Livorsi, MD, […]

POCUS educators investigate ultrasound skills retention

Point-of-care ultrasound (POCUS) has proven to be an important tool for rapid bedside assessments and diagnoses. Basic POCUS image acquisition and interpretation skills have been integrated in the Internal Medicine Residency educational curriculum. The one-hour hands-on and didactic sessions occur every 10 weeks during the residents’ Y-week as it alternates with a longitudinal primary care […]

Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment

Article: Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment Authors: Jeremy Steinman and Amal Shibli-Rahhal Journal: J Bone Metab. 2019 Aug;26(3):133-143. Abstract: Anorexia nervosa (AN) affects 2.9 million people, many of whom experience bone loss and increased fracture risk. In this article, we review data on the underlying pathophysiology of AN-related osteoporosis and possible approaches to […]

Dietary Fatty Acid Saturation Modulates Sphingosine-1-Phosphate-Mediated Vascular Function

Article: Dietary Fatty Acid Saturation Modulates Sphingosine-1-Phosphate-Mediated Vascular Function Authors: Daniel W. Nuno and Kathryn G. Lamping Journal: J Diabetes Res. 2019 Aug 25;2019:2354274 Abstract: Sphingolipids, modified by dietary fatty acids, are integral components of plasma membrane and caveolae that are also vasoactive compounds. We hypothesized that dietary fatty acid saturation affects vasoconstriction to sphingosine-1-phosphate […]

Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases

Article: Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases Authors: Rong Cai, Yu Zhang, Jacob E. Simmering, Jordan L. Schultz, Yuhong Li, Irene Fernandez-Carasa, Antonella Consiglio, Angel Raya, Philip M. Polgreen, Nandakumar S. Narayanan, Yanpeng Yuan, Zhiguo Chen, Wenting Su, Yanping Han, Chunyue Zhao, Lifang Gao, Xunming Ji, Michael J. Welsh, and […]

Effect of Early and Late Interventions with Dietary Oils on Vascular and Neural Complications in a Type 2 Diabetic Rat Model

Article: Effect of Early and Late Interventions with Dietary Oils on Vascular and Neural Complications in a Type 2 Diabetic Rat Model Authors: Lawrence Coppey, Eric Davidson, Hanna Shevalye, Alexander Obrosov, and Mark Yorek Journal: J Diabetes Res. 2019 Aug 7;2019:5020465. Abstract: Aims. Determine the effect of dietary oils enriched in different mono- or polyunsaturated […]

Link between systems leading to hypertension described

Previous studies have found that manipulating renal nerves could serve as a hypertension therapeutic in cases where pharmacological treatment is ineffective. Sailesh Harwani, MD, PhD, assistant professor in Cardiovascular Medicine, has conducted the first study that suggests the integration of adrenegic, cholingeric, and renal systems affects the development of premature hypertension. His study also is […]

An Investigation of p53 in Skeletal Muscle Aging

Article: An Investigation of p53 in Skeletal Muscle Aging Authors: Scott M. Ebert, Jason M. Dierdorff, David K. Meyerholz, Steven A. Bullard, Asma Al-Zougbi, Austin D. DeLau, Kristin C. Tomcheck, Zachary P. Skopec, George R. Marcotte, Sue C. Bodine, and Christopher M. Adams Journal: J Appl Physiol (1985). 2019 Aug 29. doi: 10.1152/japplphysiol.00363.2019. [Epub ahead […]