Inhibition of Protein Kinase C Beta Phosphorylation Activates Nuclear Factor-Kappa B and Improves Postischemic Recovery in Type 1 Diabetes

Article: Inhibition of Protein Kinase C Beta Phosphorylation Activates Nuclear Factor-Kappa B and Improves Postischemic Recovery in Type 1 Diabetes Authors: Satyanarayana Alleboina, Thomas Wong, Madhu V Singh, Ayotunde O Dokun Journal: Exp Biol Med (Maywood). 2020 May;245(9):785-796. doi: 10.1177/1535370220920832. Epub 2020 Apr 23. Abstract:Peripheral artery disease (PAD) is a major health problem and is […]

Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human Beta Cells and Critical for the Maintenance of Syntaxin1a Level in Beta Cells

Article: Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human Beta Cells and Critical for the Maintenance of Syntaxin1a Level in Beta Cells Authors: Siming Liu, Joseph A Promes, Mikako Harata, Akansha Mishra, Samuel B Stephens, Eric B Taylor, Anthony J Burand, William I Sivitz, Brian D Fink, James […]

A Typology of New Long-term Opioid Prescribing in the Veterans Health Administration

Article: A Typology of New Long-term Opioid Prescribing in the Veterans Health Administration Authors: Katherine Hadlandsmyth PhD, Hilary J. Mosher MD, Emine O. Bayman PhD, Justin G. Wikle MD & Brian C. Lund PharmD Journal: J Gen Intern Med. 2020 Mar 23. doi: 10.1007/s11606-020-05749-7. Online ahead of print. Abstract: Background: Narrow definitions of long-term opioid […]

Leadership training programs’ effectiveness evaluated

In training for a career in clinical practice or research, leadership and management skills are becoming increasingly necessary for physicians-in-training. To stay ahead of the curve, institutions have begun implementing leadership training in their graduate medical education (GME) programs. With the increased interest in leadership training, some of our GME leaders published a systematic review […]

Low FVC/TLC in Preserved Ratio Impaired Spirometry (PRISm) Is Associated With Features of and Progression to Obstructive Lung Disease

Article: Low FVC/TLC in Preserved Ratio Impaired Spirometry (PRISm) Is Associated With Features of and Progression to Obstructive Lung Disease Authors: Spyridon Fortis, Alejandro Comellas, Victor Kim, Richard Casaburi, John E Hokanson, James D Crapo, Edwin K Silverman, Emily S Wan Journal: Sci Rep. 2020 Mar 20;10(1):5169 Abstract: One quarter of individuals with Preserved Ratio […]

Khataei deepens understanding of exercise’s effects

Tahsin Khataei, PhD, research assistant in the lab of Christopher Benson, MD, says that although the mental and physical health benefits of routine exercise is widely known, many do not participate in regular exercise regimens. “One reason for this is that exercise, especially high-intensity exercise, is often accompanied by muscle pain and fatigue—felt to be […]

Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice

Article: Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice. Authors: Nirav Dhanesha, Manasa K. Nayak, Prakash Doddapattar, Manish Jain, Gagan D. Flora, Shigeyuki Kon, Anil K. Chauhan Journal: Blood. 2020 Mar 12;135(11):857-861. doi: 10.1182/blood.2019002846. Abstract:Evidence suggests that neutrophils contribute to thrombosis via several mechanisms, including neutrophil extracellular traps (NETs) formation. Integrin α9β1 is […]