Link between systems leading to hypertension described

Previous studies have found that manipulating renal nerves could serve as a hypertension therapeutic in cases where pharmacological treatment is ineffective. Sailesh Harwani, MD, PhD, assistant professor in Cardiovascular Medicine, has conducted the first study that suggests the integration of adrenegic, cholingeric, and renal systems affects the development of premature hypertension. His study also is […]

An Investigation of p53 in Skeletal Muscle Aging

Article: An Investigation of p53 in Skeletal Muscle Aging Authors: Scott M. Ebert, Jason M. Dierdorff, David K. Meyerholz, Steven A. Bullard, Asma Al-Zougbi, Austin D. DeLau, Kristin C. Tomcheck, Zachary P. Skopec, George R. Marcotte, Sue C. Bodine, and Christopher M. Adams Journal: J Appl Physiol (1985). 2019 Aug 29. doi: 10.1152/japplphysiol.00363.2019. [Epub ahead […]

Iowa TelePrEP: A Public-Health-Partnered Telehealth Model for Human Immunodeficiency Virus Preexposure Prophylaxis Delivery in a Rural State

Article: Iowa TelePrEP: A Public-Health-Partnered Telehealth Model for Human Immunodeficiency Virus Preexposure Prophylaxis Delivery in a Rural State Authors: Hoth, Angela B. PharmD, MPH; Shafer, Cody; Dillon, Dena Behm PharmD; Mayer, Randy MS, MPH; Walton, George MPH; Ohl, Michael E. MD, MSPH¶ Journal: Sexually Transmitted Diseases: August 2019, 46(8):507–512 Abstract: Background: Access to human immunodeficiency […]

Hospital responses to Ebola reviewed

From 2014 to 2016, more than 28,000 cases of Ebola were reported in West African countries Guinea, Liberia, and Sierra Leone. This highly infectious disease became an international health emergency, with seven other countries also becoming affected. With eleven cases treated in the United States, analyzing the quality of responsiveness among hospitals across the nation […]

Trastuzumab and pertuzumab in circulating tumor DNA ERBB2-amplified HER2-positive refractory cholangiocarcinoma

Article: Trastuzumab and pertuzumab in circulating tumor DNA ERBB2-amplified HER2-positive refractory cholangiocarcinoma Authors: Bhavya Yarlagadda, Vaishnavi Kamatham, Ashton Ritter, Faisal Shahjehan & Pashtoon M. Kasi Journal: npj Precision Oncologyvolume 3, Article number: 19 (2019) Abstract: Cholangiocarcinoma is a heterogeneous and target-rich disease with differences in actionable targets. Intrahepatic and extrahepatic types of cholangiocarcinoma differ significantly […]

Novel functions of inactive rhomboid proteins in immunity and disease

Article: Novel functions of inactive rhomboid proteins in immunity and disease Authors: Ramasatyaveni Geesala, Priya D. Issuree, Thorsten Maretzky Journal: J Leukoc Biol 2019;1–13 Abstract: iRhoms are related to a family of intramembrane serine proteinases called rhomboids but lack proteolytic activity. In mammals, there are two iRhoms, iRhom1 and iRhom2, which have similar domain structures […]

Embedding a longitudinal diagnostic reasoning curriculum in a residency program using a bolus/booster approach

Article: Embedding a longitudinal diagnostic reasoning curriculum in a residency program using a bolus/booster approach Authors: Katherine I. Harris, Jane S. Rowat, Manish Suneja Journal: Diagnosis (Berl). 2019 Jul 27. doi: 10.1515/dx-2019-0023. [Epub ahead of print] Abstract: Background Diagnostic reasoning skills are essential to the practice of medicine, yet longitudinal curricula to teach residents and […]

Interstitial lung disease associated with anti-PM-Scl antibody: A single center experience

Article: Interstitial lung disease associated with anti-PM-Scl antibody: A single center experience Authors: Kamonpun Ussavarungsi, Kenneth Nugent, Alicia K. Gerke, Matthew D. Krasowski, Rebecca S. Tuetken, Petar S. Lenert Journal: Autoimmun Rev. 2019 Jul 16:102355. doi: 10.1016/j.autrev.2019.102355. [Epub ahead of print] Excerpt: Anti-PM-Scl antibody was one of first with nucleolar specificity described as a marker […]

Iowa researchers identify commonalities among effective rapid response teams

Rapid response teams (RRTs) are highly specialized hospital emergency teams that treat patients who develop a sudden worsening of their clinical condition, which if not treated can be life-threatening. However, prior studies of the effectiveness of RRTs have shown varied results, leading some to suggest these teams are irrelevant, while others have argued they are […]

Potential new front opens against parasite

In Africa, the Middle East, Mexico, Asia, and South America, more than one billion people are at risk of contracting leishmaniasis, a disease spread through sandflies and caused by the parasite Leishmania major, which manifests most commonly as skin lesions but with the potential for more harmful internal damage. Leishmaniasis mainly affects people in tropical […]