Implementation of Clinical Practice Guidelines for Hospitalized Patients With COVID-19 in Academic Medical Centers

Article: Implementation of Clinical Practice Guidelines for Hospitalized Patients With COVID-19 in Academic Medical Centers Authors: Amy Chang Berger, Noa Simchoni, Andrew Auerbach, W Michael Brode, Ethan Kuperman, Katie Raffel, Alan Kubey, HOMERuN COVID-19 Collaborative Group Journal: JAMA Netw Open. 2022 Apr 1;5(4):e225657. doi: 10.1001/jamanetworkopen.2022.5657. Abstract: This survey study assesses the rate at which US […]

Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment

Article: Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment Authors: Nicholas Borcherding, Kevin J Severson, Nicholas Thomas Henderson, Luana Dos Santos Ortolan, Allison C Rosenthal, Andrew M Bellizzi, Vincent Liu, Brian K Link, Aaron R Mangold, Ali Jabbari Journal: Blood Adv. 2022 Apr 7;bloodadvances.2021005991. doi: 10.1182/bloodadvances.2021005991. Online ahead […]

CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element

Article: CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element Authors: Athmane Teghanemt, Priyanjali Pulipati, Kara Misel-Wuchter, Kenneth Day, Matthew S Yorek , Ren Yi, Henry L Keen, Christy Au, Thorsten Maretzky, Prajwal Gurung, Dan R Littman, Priya D Issuree Journal: Nat Commun. 2022 Mar 18;13(1):1477. Abstract: The […]

Avacopan: An Oral Complement 5a Inhibitor for ANCA-associated Vasculitis

Article: Avacopan: An Oral Complement 5a Inhibitor for ANCA-associated Vasculitis Authors: Matthew J Mandell, Gatr-Alnada Gheriani, Aleksander Lenert, Petar S Lenert Journal: touchREVIEWS in RMD 2022;1(1):Online ahead of publication Abstract: The oral complement 5a receptor antagonist, avacopan, was recently studied in phase II and III clinical trials in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis […]

Blocking ceramides with fungi extract reverses diabetes, obesity, in mice

A publication earlier this month in Scientific Reports demonstrates that a key lipid metabolite may be a useful target in preventing or even reversing diabetes and many of its comorbidities. Ceramides are a characteristic of obesity, and increased accumulation of these metabolites contributes to glucose and metabolism impairments. In rodents, ceramide degradation prevented and reversed […]

Association of Nonobstructive Chronic Bronchitis With All-Cause Mortality

Article: Association of Nonobstructive Chronic Bronchitis With All-Cause Mortality Authors: Spyridon Fortis, MD, Zacariah K. Shannon, DC, Crystal J. Garcia, Rodrigo Vazquez Guillamet, MD, Ariel M. Aloe, PhD, Marin L. Schweizer, PhD, Victor Kim, MD, Rajeshwari Nair, PhD Journal: Chest. 2022 DOI:https://doi.org/10.1016/j.chest.2022.02.003 Abstract: Background: The effect of nonobstructive chronic bronchitis (CB) on mortality is unclear. […]

Perceptions of risk of SARS-CoV-2 transmission in social and educational activities by infectious diseases and general pediatric healthcare providers, a pre-vaccine risk perception cross-sectional survey

Article: Perceptions of risk of SARS-CoV-2 transmission in social and educational activities by infectious diseases and general pediatric healthcare providers, a pre-vaccine risk perception cross-sectional survey Authors: Andrew B Janowski, Philip M Polgreen, Susan E Beekmann, Jason G Newland Journal: PLoS One. 2022 Feb 11;17(2):e0263767 Abstract: Background: The perception of the transmission risks of SARS-CoV-2 […]

TREM-1 is required for enhanced OpZ-induced superoxide generation following priming

Article: TREM-1 is required for enhanced OpZ-induced superoxide generation following priming Authors: Shubha Murthy, Sankar Baruah, Jayden L Bowen, Kathy Keck, Brett A Wagner, Garry R Buettner, David B Sykes, Julia Klesney-Tait Journal: J Leukoc Biol. 2022 Jan 24. doi: 10.1002/JLB.3A0421-212R. Online ahead of print. Abstract: Inflammatory agents, microbial products, or stromal factors pre-activate or […]

The Role of Clinical Features and Serum Biomarkers in Identifying Patients with Incomplete Lupus Erythematosus at Higher Risk of Transitioning to Systemic Lupus Erythematosus: Current Perspectives

Article: The Role of Clinical Features and Serum Biomarkers in Identifying Patients with Incomplete Lupus Erythematosus at Higher Risk of Transitioning to Systemic Lupus Erythematosus: Current Perspectives Authors: Erin Sternhagen, Brittany Bettendorf, Aleksander Lenert, Petar S Lenert Journal: J Inflamm Res. 2022 Feb 18;15:1133-1145. Abstract: Discovery of antinuclear antibodies (ANA) enabled earlier diagnosis of systemic […]

Dokun, national panel update diabetes care recommendations for US Congress

In January, the National Clinical Care Commission (NCCC), a panel funded by the United States Department of Health and Human Services (HHS) completed its three-year mission and submitted a report updating recommendations on the care of diabetes-related complex metabolic and autoimmune diseases to the US Secretary of HHS and the US Congress. Ayotunde Dokun, MD, […]