Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

Article: Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron Authors: Jonathan Cedernaes, Wenyu Huang, Kathryn Moynihan Ramsey, Nathan Waldeck, Lei Cheng, Biliana Marcheva, Chiaki Omura, Yumiko Kobayashi, Clara Bien Peek, Daniel C. Levine, Ravindra Dhir, Raj Awatramani, Christopher A. Bradfield, Xiaozhong A. Wang, Joseph S. Takahashi, Mohamad Mokadem, Rexford S. […]

Angiotensin II-induced Hypertension and Cardiac Hypertrophy are Differentially Mediated by TLR3- and TLR4-Dependent Pathways

Article: Angiotensin II-induced Hypertension and Cardiac Hypertrophy are Differentially Mediated by TLR3- and TLR4-Dependent Pathways Authors: Madhu V. Singh, Michael Z. Cicha, Sarah Nunez, David K. Meyerholz, Mark W. Chapleau, Francois M. Abboud Journal: Am J Physiol Heart Circ Physiol. 2019 Feb 22. doi: 10.1152/ajpheart.00697.2018. [Epub ahead of print] Abstract: Toll-like receptors (TLR) are key […]

One size does not protect all

Loreen Herwaldt, MD, professor in Infectious Diseases and of Epidemiology, and Priyadarshini Pennathur, PhD, assistant professor in Industrial and Systems Engineering, presented an invited talk on personal protective equipment (PPE) design problems to a standing committee within the National Academies of Sciences, Engineering, and Medicine. The committee is tasked with, in part, addressing topics that […]

Regulation of cardiac transcription by thyroid hormone and Med13

Article: Regulation of cardiac transcription by thyroid hormone and Med13 Authors: Rachel A. Minerath, Colleen M. Dewey, Duane D. Hall, Chad E. Grueter Journal: J Mol Cell Cardiol. 2019 Feb 12;129:27-38 Abstract: Thyroid hormone (TH) is a key regulator of transcriptional homeostasis in the heart. While hypothyroidism is known to result in adverse cardiac effects, […]

Better measurements for better predictions

The genetic disorder Duchenne muscular dystrophy (DMD) occurs when there is a lack of the protein dystrophin, causing progressively weak muscle development in children and a shorter life span. Once children begin steroid treatment, their bones become very fragile and experience delays in growth. Dual X-ray absorptiometry, or DXA scans, which are used to monitor […]

Innate post-AKI repair process insufficient for full recovery

Acute injuries of the kidney, which cause temporary loss of kidney function, were believed to be harmless and the kidneys could make a full recovery following these episodes. However, more research revealed that any insult to the kidneys sets up a slow loss of functional nephrons and progressive formation of fibrotic scars. Massimo Attanasio, MD, […]

Mosher triples on JHM top articles list

Hilary Mosher, MD, associate professor in General Internal Medicine, had a productive 2018 and with no small amount of impact. In its January newsletter, the Journal of Hospital Medicine issued its “Top 10 Articles of 2018” list. With entries in multiple categories from Original Research to Reviews, three of the articles chosen were ones to […]

Smoking cessation benefits from professional intervention

People with rheumatoid arthritis and lupus tend to use smoking as a relief from their pain or as a “crutch,” but smoking can increase the severity of cardiovascular and rheumatic diseases. However, only 10 percent of rheumatology visits include cessation counseling, according to a new study published in Arthritis Care & Research co-authored by Brittany […]

Diagnosis of monogenic chronic kidney diseases

Article: Diagnosis of monogenic chronic kidney diseases Authors: Margaret Armstrong, Christie Thomas Journal: Curr Opin Nephrol Hypertens. 2019 Mar;28(2):183-194 Abstract: PURPOSE OF REVIEW: The purpose of this review is to emphasize that single gene disorders are an important and sometimes unrecognized cause of progressive chronic kidney disease. We provide an overview of the benefits of […]