Perilipin2 down-regulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria

Article: Perilipin2 down-regulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria Authors: Akansha Mishra, Siming Liu, Joseph Promes, Mikako Harata, William I. Sivitz, Brian D. Fink, Gourav Bhardwaj, Brian T. O’Neill, Chen Kang, Rajan Sah, Stefan Strack, Samuel B. Stephens, Timothy H. King, Laura Jackson, Andrew S. Greenberg, Frederick Anokye-Danso, Rexford […]

Hand hygiene and the sequence of patient care

Article: Hand hygiene and the sequence of patient care Authors: Nai-Chung Chang, Michael Jones, Heather Schacht Reisinger, Marin L Schweizer, Elizabeth Chrischilles, Margaret Chorazy, W Charles Huskins, Loreen Herwaldt Journal: Infect Control Hosp Epidemiol. 2021 Apr 6;1-6. doi: 10.1017/ice.2021.82. Online ahead of print. Abstract:Objective: To determine whether the order in which healthcare workers perform patient […]

Palliative care consultation in patients with Staphylococcus aureus bacteremia

Article: Palliative care consultation in patients with Staphylococcus aureus bacteremia Authors: Takaaki Kobayashi, Jorge L Salinas, Patrick Ten Eyck, Benjamin Chen, Tomo Ando, Kengo Inagaki, Mohammed Alsuhaibani, Paul G Auwaerter, Ilonka Molano, Daniel J Diekema Journal: Palliat Med. 2021 Apr;35(4):785-792. Abstract:Background: Palliative care consultation has shown benefits across a wide spectrum of diseases, but the […]

Maintenance of muscle mass in adult male mice is independent of testosterone

Article: Maintenance of muscle mass in adult male mice is independent of testosterone Authors: Arik Davidyan, Suraj Pathak, Keith Baar, Sue C Bodine Journal: PLoS One. 2021 Mar 25;16(3):e0240278. Abstract: Testosterone is considered a potent anabolic agent in skeletal muscle with a well-established role in adolescent growth and development in males. However, the role of […]

Transcatheter Valve Implantation in a Severely Regurgitant Apicoaortic Conduit

Article: Transcatheter Valve Implantation in a Severely Regurgitant Apicoaortic Conduit Authors: Phanicharan A Sistla, Prashob Porayette, Osamah T Aldoss, Sidakpal S Panaich Journal: JACC Cardiovasc Interv. 2021 Mar 22;14(6):e53-e56. Excerpt: A 33-year-old woman with congenital bicuspid aortic stenosis had a complex surgical history, which included aortic valve replacement with a 21-mm Freestyle bioprosthesis (Medtronic, Dublin, […]

Reith guides Cancers pub, models Iowa-style mentoring

Novel treatments for melanoma over the past decade have dramatically enhanced survival. Immune checkpoint inhibitors and BRAF/MEK inhibitors have both demonstrated significant improvements in melanoma patient outcomes as demonstrated by many clinical trials. Unfortunately, patients who develop brain metastases still carry a grim prognosis, with a median overall survival of fewer than 6 months. Additionally, there is relatively […]

Serrated polyp detection rate and advanced adenoma detection rate from a US multicenter cohort

Article: Serrated polyp detection rate and advanced adenoma detection rate from a US multicenter cohort Authors: Jagpal S Klair, Munish Ashat, Dane Johnson, Sumant Arora, Nirmal Onteddu, Jose G Machain Palacio, Ronald Samuel, Mohammad Bilal, Avanija Buddam, Ashutosh Gupta, Alan Gunderson, Praveen Guturu, Kaartik Soota, Subhash Chandra, Arvind R Murali Journal: Endoscopy. 2020 Jan;52(1):61-67. doi: […]

Strong mentoring nets Rytlewski pair of pubs, career guidance

With a median overall survival rate of one year, metastatic sarcomas pose a substantial threat to patient wellbeing. Although current treatment plans include traditional therapies, such as radiation and chemotherapy, sarcomas’ multiple subtypes require more specific treatment. Third-year resident Jeff Rytlewski, MD, is first author on two articles reviewing the barriers and prospects of sarcoma therapies. […]

Smooth Muscle Cell-Specific PKM (Pyruvate Kinase M) 2 Promotes Smooth Muscle Cell Phenotypic Switching and Neointimal Hyperplasia

Article: Smooth Muscle Cell-Specific PKM (Pyruvate Kinase M) 2 Promotes Smooth Muscle Cell Phenotypic Switching and Neointimal Hyperplasia Authors: Manish Jain, Nirav Dhanesha, Prakash Doddapattar, Manasa K Nayak, Liang Guo, Anne Cornelissen, Steven R Lentz, Aloke V Finn, Anil K Chauhan Journal: Arterioscler Thromb Vasc Biol. 2021 Mar 11;ATVBAHA121316021. Online ahead of print. Abstract:Objective: The […]

Ratio of Forced Expiratory Volume in 1 second /Slow Vital Capacity (FEV 1/SVC)<0.7 is associated with clinical, functional, and radiologic features of obstructive lung disease in smokers with preserved lung function

Article: Ratio of Forced Expiratory Volume in 1 second /Slow Vital Capacity (FEV 1/SVC)<0.7 is associated with clinical, functional, and radiologic features of obstructive lung disease in smokers with preserved lung function Authors: Spyridon Fortis, Alejandro Comellas, Surya P Bhatt, Eric A Hoffman, MeiLan K Han, Nirav R Bhakta, Robert Paine 3rd, Bonnie Ronish, Richard […]