Article: Can Artificial Intelligence Enhance Syncope Management?: A JACC: Advances Multidisciplinary Collaborative Statement Authors: Giselle M. Statz, Aron Z. Evans, Samuel L. Johnston, Mehul Adhaduk, Avinash R. Mudireddy, Milan Sonka, Sangil Lee, E. John Barsotti, Fabrizio Ricci, Franca Dipaola, Madeleine Johansson, Robert S. Sheldon, Venkatesh Thiruganasambandamoorthy, Rose-Anne Kenny, Tyler C. Bullis, Deepak K. Pasupula, Jon […]
Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma
Article: Loss of Nf1 and Ink4a/Arf Are Associated with Sex-Dependent Growth Differences in a Mouse Model of Embryonal Rhabdomyosarcoma Authors: Wade R Gutierrez, Jeffrey D Rytlewski, Amanda Scherer, Grace A Roughton, Nina C Carnevale, Krisha Y Vyas, Gavin R McGivney, Qierra R Brockman, Vickie Knepper-Adrian, Rebecca D Dodd Journal: Curr Issues Mol Biol. 2023 Feb […]
Patients’ experiences and compliance with preoperative screening and decolonization
Article: Patients’ experiences and compliance with preoperative screening and decolonization Authors: Ethan Wilson, Alexandre R Marra, Melissa Ward, Laura Chapin, Stephanie Boulden, Timothy C Ryken, Lynne C Jones, Loreen A Herwaldt Journal: Am J Infect Control. 2023 Jan;51(1):78-82 Abstract: Background: To improve adherence with pre-surgical screening for Staphylococcus aureus nasal carriage and decolonization, we need […]
WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release
Article: WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release Authors: Xin Jin, Jian Xie, Chia-Wei Yeh, Jen-Chi Chen, Chih-Jen Cheng, Cheng-Chang Lien, Chou-Long Huang Journal: J Clin Invest. 2023 Apr 18;e164222 Abstract: Maintaining internal osmolality constancy is essential for life. Release of arginine vasopressin (AVP) responding to hyperosmolality […]
Differential engagement of inhibitory and excitatory cardiopulmonary reflexes by capsaicin and phenylbiguanide in C57BL/6 mice
Article: Differential engagement of inhibitory and excitatory cardiopulmonary reflexes by capsaicin and phenylbiguanide in C57BL/6 mice Authors: Robert A Larson, Mark W Chapleau Journal: Am J Physiol Regul Integr Comp Physiol. 2023 Mar 1;324(3):R336-R344 Abstract: The Bezold-Jarisch reflex is a powerful inhibitory reflex initiated by activation of cardiopulmonary vagal nerves during myocardial ischemia, hemorrhage, and […]
Evaluation of Empirical Dosing Regimens for Meropenem in Intensive Care Unit Patients Using Population Pharmacokinetic Modeling and Target Attainment Analysis
Article: Evaluation of Empirical Dosing Regimens for Meropenem in Intensive Care Unit Patients Using Population Pharmacokinetic Modeling and Target Attainment Analysis Authors: Guohua An, C Buddy Creech, Nan Wu, Roger L Nation, Kenan Gu, Demet Nalbant, Natalia Jimenez-Truque, William Fissell, Stephanie Rolsma, Pratish C Patel, Amy Watanabe, Nicholas Fishbane, Carl M J Kirkpatrick, Cornelia B […]
How can we champion diversity, equity and inclusion within Lean Six Sigma? Practical suggestions for quality improvement
Article: How can we champion diversity, equity and inclusion within Lean Six Sigma? Practical suggestions for quality improvement Authors: Bharat Kumar, Hilary Mosher, Amany Farag, Melissa Swee Journal: BMJ Qual Saf. 2022 Dec 29;bmjqs-2022-014892 Excerpt: Lean Six Sigma (LSS) is a quality improvement (QI) methodology that has gained popularity in recent decades in health care […]
The effect of gender and obesity in modulating cross-bridge function in cardiac muscle fibers
Article: The effect of gender and obesity in modulating cross-bridge function in cardiac muscle fibers Authors: Jing Xi, Yuanchao Ye, Mohamad Mokadem, Jinxiang Yuan, Masataka Kawai Journal: J Muscle Res Cell Motil. 2022 Dec;43(4):157-172 Abstract: The effect of obesity on cross-bridge (CB) function was investigated in mice lacking functional Melanocortin-4 Receptor (MC4R-/-), the loss of […]
Optimization of Neoadjuvant Therapy for Early-Stage Triple-Negative and HER2 + Breast Cancer
Article: Optimization of Neoadjuvant Therapy for Early-Stage Triple-Negative and HER2 + Breast Cancer Author: Sneha Phadke Journal: Curr Oncol Rep. 2022 Dec;24(12):1779-1789 Abstract: Purpose of review: Neoadjuvant, or pre-operative, therapy for the treatment of early-stage breast cancer has several potential benefits, especially for patients with triple-negative or HER2 + subtypes. This review provides an overview […]
Plasticity of cerebral microvascular structure and mechanics during hypertension and following recovery of arterial pressure
Article: Plasticity of cerebral microvascular structure and mechanics during hypertension and following recovery of arterial pressure Authors: Rasna Sabharwal, Mark W Chapleau, Thomas D Gerhold, Gary L Baumbach, Frank M Faraci Journal: Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1108-H1117 Abstract: Changes in vascular structure contribute to vascular events and loss of brain health. […]