Polarized AAVR expression determines infectivity by AAV gene therapy vectors

Article: Polarized AAVR expression determines infectivity by AAV gene therapy vectors Authors: Bradley A. Hamilton, Xiaopeng Li, Alejandro A. Pezzulo, Mahmoud H. Abou Alaiwa & Joseph Zabner Journal: Gene Therapy volume 26, pages240–249 (2019) Abstract: Adeno-associated virus (AAV) has been investigated to transfer the cystic fibrosis transmembrane conductance regulator (CFTR) to airways. Inhaled AAV2-CFTR in […]

Zika knowledge and conspiracy beliefs share similar psychological motivations

“Infectious disease outbreaks can induce feelings of threat, uncertainty, and loss of control in people, feelings that have been associated with both increased information seeking and the emergence of conspiracy theories,” Aaron Scherer, PhD, associate in General Internal Medicine, said. Consistent with his past studies, Scherer conducted yet another survey-based study assessing the factors that […]

Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells

Article: Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells Authors: Shelby C. Bearrows, Casey J. Bauchle, McKenzie Becker, Jonathan M. Haldeman, Svetha Swaminathan, Samuel B. Stephens Journal: J Cell Sci. 2019 Jul 1;132(13) Abstract: Chromogranin B (CgB, also known as CHGB) is abundantly expressed in dense core secretory granules […]

From the Editor: Getting started getting published

I recently spoke at a residents’ noon conference about the basics of manuscript writing. Although residents are encouraged to write and submit papers, it may be a daunting task for those without a lot of writing experience. My goal was to provide tips for writing and organizing a paper, and to help with deciphering some […]

Coronary Spasm and Polymorphic Ventricular Tachycardia One Year After Takotsubo

Article: Coronary Spasm and Polymorphic Ventricular Tachycardia One Year After Takotsubo Authors: Noah N. Williford MD, Alexander Mazur MD, Troy Rhodes MD, PhD, Elaine Demetroulis MD, Milena A. Gebska MD, PhD Journal: Mayo Clin Proc Innov Qual Outcomes. 2019 Jun; 3(2): 231–234. Abstract: Stress cardiomyopathy is typically considered to be a disease with a favorable […]

Tau interacts with SHP2 in neuronal systems and in Alzheimer’s disease

Article: Tau interacts with SHP2 in neuronal systems and in Alzheimer’s disease Authors: Yohan Kim, Guanghao Liu, Chad J. Leugers, Joseph D. Mueller, Meghan B. Francis, Marco M. Hefti, Julie A. Schneider, Gloria Lee Journal: J Cell Sci. 2019 Jun 14. pii: jcs.229054. doi: 10.1242/jcs.229054. [Epub ahead of print] Abstract: Microtubule-associated protein tau, an integral […]

Renal Denervation and CD161a Immune Ablation Prevent Cholinergic Hypertension and Renal Sodium Retention

Article: Renal Denervation and CD161a Immune Ablation Prevent Cholinergic Hypertension and Renal Sodium Retention Authors: Nandita S Raikwar, Cameron Braverman, Peter M. Snyder, Robert A. Fenton, David K. Meyerholz, Francois M. Abboud, and Sailesh C. Harwani Journal: Am J Physiol Heart Circ Physiol. 2019 Jun 7. doi: 10.1152/ajpheart.00234.2019. [Epub ahead of print] Abstract: RATIONALE: Cholinergic […]

Preliminary findings from a concise emergency department model to predict anaphylaxis and develop a clinical decision support tool

Article: Preliminary findings from a concise emergency department model to predict anaphylaxis and develop a clinical decision support tool Authors: Sangil Lee MD, MS, Cassandra Hardy BS, Morgan Bobb Swanson BS, Karisa Harland MPH, PhD, Azeemuddin Ahmed MD, MBA and Zuhair Ballas MD Journal: J Allergy Clin Immunol Pract. 2019 Apr 9. pii: S2213-2198(19)30373-3. doi: […]

Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children: Prevalence, Predictors of Survival, and Implications for Hospital Profiling

Article: Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children: Prevalence, Predictors of Survival, and Implications for Hospital Profiling Authors: Rohan Khera, Yuanyuan Tang, Saket Girotra, Vinay M. Nadkarni, Mark S. Link, Tia T. Raymond, Anne-Marie Guerguerian, Robert A. Berg, and Paul S. Chan Journal: Circulation. 2019 Apr 22. doi: 10.1161/CIRCULATIONAHA.118.039048. [Epub ahead […]

Strengthening our culture of scholarship

I am writing to share my perspectives on scholarship in our department, how we support and enhance it, and how it should be measured. The University of Iowa is internationally recognized for its research output, and the Department of Internal Medicine has been an important contributor to our university’s academic reputation. Our research productivity wins […]