Post-TAVR risks examined in large cohort analysis

The transcatheter aortic valve replacement (TAVR) procedure replaces a narrow aortic valve that obstructs normal blood flow with a catheter. Three years ago an estimated 300,000 TAVRs had been performed. That number has climbed dramatically since and will continue with the recent FDA approval for expansion of TAVR procedures to even low-risk patients with severe […]

Big data expands understanding even in rare diseases

Adult-onset Still’s disease (AOSD) is a rare autoinflammatory disease driven by the innate immune system leading to clinical manifestations of fever, rash, and arthritis. Additionally, AOSD patients can present with severe complications at onset including macrophage activation syndrome (MAS) and lung disease. Because large prospective cohorts of AOSD patients are lacking, research into long-term clinical […]

Big data and big discoveries

Happy New Year, Happy 2020! I hope the past couple weeks have been restorative, whether you were able to take a lot or even a little time away from work and for yourself. The turning of the calendar to a new year and a new decade may be an arbitrary time for the establishment of […]

53rd Annual Internal Medicine Research Day, 10/15/19

Since the tradition began in the early 1960s, Research Day has seen a variety of formats. But what has always been at its core was the celebration of the diversity and depth of the work being done by a panoply of trainees, clinicians, and basic scientists. Better understanding a disease mechanism or testing a new […]