Grumbach collaboration to examine impact of radiation on blood vessels

Isabella Grumbach, MD, PhD, professor in Cardiovascular Medicine, and Randy Kardon, MD, PhD, professor of Ophthalmology and Visual Sciences, received a five-year, R01 grant for $2.5 million from the National Institutes of Health. The duo will study the effects of radiation therapy on small blood vessels, also known as microvessels, in cancer survivors. Every year, […]

Diabetes research enters “the matrix”

Coming soon to a public television stations across the country! Hosted by the television and film actor Laurence Fishburne, the program Information Matrix profiles innovative and exceptional organizations and individuals. An episode titled “Reversing Diabetes” brought a film crew to Iowa City in order to document the work being done within the Fraternal Order of […]

Grumbach receives HCCC pilot grant

Isabella Grumbach, MD, PhD, professor in Cardiovascular Medicine, received a one-year $20,000 pilot grant from the University of Iowa’s Holden Comprehensive Cancer Center (HCCC). The HCCC’s funding will support Grumbach’s proposed investigation to identify FDA-approved drugs used for other treatments that could also prevent damage to the cells lining blood vessels following radiation treatment. By […]

Grumbach Receives AHA Grant to Study Microvessel Damage

Isabella Grumbach, MD, Professor in Cardiovascular Medicine, has received a two-year, $200,000 Innovative Project Award from the American Heart Association. In a project titled “New models of radiation endotheliopathy,” Dr. Grumbach will investigate the effects or radiation on small blood vessels. Specifically, she and her colleagues will employ new technologies to examine vasculature in the […]

Grumbach Named to NIH Study Section

Isabella Grumbach, MD, PhD, Associate Professor in Cardiovascular Medicine, has accepted an invitation to join the Vascular Cell and Molecular Biology study section of the NIH’s Center for Scientific Review. During her six-year term, Dr. Grumbach will review and make recommendations on grant applications submitted to the NIH, as well as continuously survey the status […]

AHA Grants to Internal Medicine

The American Heart Association has recently approved a round of funding for multiple members of the Department. Two Winter 2017 Grant-in-Aid awards each totaling $154,000 are set to begin July 1 and will continue through the end of June 2019. In her project, Dr. Isabella Grumbach, Vice Chair for Research, will focus on how mitochondria […]

Grumbach VA Merit Grant Funded

Dr. Isabella Grumbach, Associate Professor of Cardiovascular Medicine, has just had her VA Merit proposal funded with a four-year, $650,000 grant. Dr. Grumbach provided a detailed description of what she and the researchers in her lab will study: At least 30% of the estimated three million veterans with hypertension do not reach the current target […]

Collaboration and Appreciation

An important aspect of our work in the Department of Internal Medicine is to find ways to collaborate with our colleagues both within the walls of the institution as well as those outside them. This, in part, is why our Continuing Medical Education programs are so critical. Recently, the Division of Endocrinology and Metabolism invited […]

CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+dependent apoptosis

AUTHORS: Christopher J. Winters, Olha Koval, Shubha Murthy, Chantal Allamargot, Sara C. Sebag, John D. Paschke, Omar A. Jaffer, A. Brent Carter, Isabella M. Grumbach JOURNAL: American Journal of Physiology – Lung Cellular and Molecular Physiology, 1 January 2016, 310(1):L86-L94 DOI: 10.1152/ajplung.00132.2015 Abstract: The calcium and calmodulin-dependent kinase II (CaMKII) translates increases in intracellular Ca2+ […]