Kumar examines SUMOs’ role in endothelial dysfunction

Santosh Kumar, PhD, associate in Cardiovascular Medicine, received a five-year, $2M grant from the NIH’s National Heart, Lung, and Blood Institute for his project “SUMO2-p66shc axis in vascular endothelial dysfunction and atherosclerosis.” With this R01, he will investigate the expression of the gene SUMO2 in the lining of arteries and veins, the correlation between SUMO2ylation […]

Kumar highlights role of hyper-SUMOylation in vascular endothelial function impairment

Small ubiquitin-like modifier (SUMO) proteins are a family of small proteins that modify the function of other proteins in cells. SUMOylation refers to posttranslational modifications by these proteins. Previous studies have revealed excessive SUMOylation can cause dysfunction in the endothelium lining of the heart and heart vessels, causing stroke, sudden cardiac death and other vascular […]

July 2017 – Santosh Kumar

Loyalty is a factor often overlooked in the pursuit of scientific advancement. And yet in the case of some recent publications and discoveries emerging from the Department of Internal Medicine, loyalty among colleagues has made a large difference. Dr. Santosh Kumar, then a postdoctoral fellow in vascular biology, was on a holiday break between semesters […]

Two Publications Identify “Longevity” Enzyme Interactions

For the last couple decades, a particular enzyme has been the focus of intense study. Sirtuin1 was found to be a key protein affecting the longevity of some organisms such as yeast. Decrease in caloric intake, which could lengthen cell life, became ineffective in the absence of sirtuin1. At the time of its discovery it […]