Isabella Grumbach, MD, PhD, professor in Cardiovascular Medicine, and Randy Kardon, MD, PhD, professor of Ophthalmology and Visual Sciences, received a five-year, R01 grant for $2.5 million from the National Institutes of Health. The duo will study the effects of radiation therapy on small blood vessels, also known as microvessels, in cancer survivors. Every year, […]
E. Dale Abel, MD, PhD, will be awarded a four-year $3.8M grant from the American Heart Association (AHA) to investigate mechanisms that increase the risk of cardiovascular disease in people with type 2 diabetes. Abel will oversee a Strategically Focused Research Network (SFRN) of three projects in partnership with other UI departments and the Massachusetts […]
Article: Inhibition of CaMKII in mitochondria preserves endothelial barrier function after irradiation Authors: Stephen J. Roy, Olha M. Koval, Sara C. Sebag, Karima Ait-Aissa, Bryan G. Allen, Douglas R. Spitz, Isabella M. Grumbach Journal: Free Radic Biol Med. 2019 Nov 9. pii: S0891-5849(19)31518-7 Abstract: Damage to the microvascular endothelium is an important part of normal […]
Although a definitive explanation for why multiple organ dysfunction system (MODS) occurs has yet to be found, solutions for treating it are beginning to emerge. Paloma Giangrande, PhD, associate professor in Hematology, Oncology and Blood and Marrow Transplantation, is senior author on a study published last month in Nature Communications investigating the treatment of MODS […]
Isabella Grumbach, MD, Professor in Cardiovascular Medicine, has received a two-year, $200,000 Innovative Project Award from the American Heart Association. In a project titled “New models of radiation endotheliopathy,” Dr. Grumbach will investigate the effects or radiation on small blood vessels. Specifically, she and her colleagues will employ new technologies to examine vasculature in the […]