Polgreen, Miller’s work named among ‘Best Research Papers’

Senior author Phil Polgreen, MD, MPH, professor in the Division of Infectious Diseases, has received a “Best Research Paper Award” from the University of Iowa Carver College of Medicine as part of its new initiative to highlight innovative biomedical research. Aaron Miller, PhD, research assistant professor of Infectious Diseases, is the paper’s lead author.

The article, “Cystic Fibrosis Carriers are at Increased Risk for a Wide Range of Cystic Fibrosis-Related Conditions.” was named the Best Clinical Research Paper by the college’s selection team.

From the award announcement:

Miller, Polgreen, and others investigate whether people who are carriers of cystic fibrosis are at greater risk for developing health conditions that mirror those by patients with cystic fibrosis, a condition manifested when two autosomal recessive genes for CFTR are inherited. In an expansive informatics analysis using health insurance claims data, the team reports that there is indeed an increased risk for CF-related conditions for carriers of recessive CFTR alleles. The authors conclude that while the risk to individual CF carriers is low, the fact that there are 10 million carriers in the U.S. alone may make such morbidity substantial overall and motivate broader genetic testing.

The article was published in the January 2020 issue of the Proceedings of the National Academy of Sciences USA, and other authors include Internal Medicine faculty members Alejandro Comellas, Douglas Hornick, David Stoltz, Alicia Gerke, Michael Welsh, and Joseph Zabner.

The selection committee cited other research “papers of note” included those from these Internal Medicine authors:

Mohamed Mokadem, et al. Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Rep. 2020 Oct 27;33(4):108270.

Anil Chauhan, et al. Smooth muscle cell-specific fibronectin-EDA mediates phenotypic switching and neointimal hyperplasia. J Clin Invest. 2020 Jan 2;130(1):295-314.

See the rest of the award winners and other papers of note at the Carver College of Medicine’s website.

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