Article: Combined FEV1 and FVC Bronchodilator Response, Exacerbations, and Mortality in COPD Authors: Spyridon Fortis, Alejandro Comellas, Barry J Make, Craig P Hersh, Sandeep Bodduluri, Dimitris Georgopoulos, Victor Kim, Gerard J Criner, Mark T Dransfield, and Surya P Bhatt Journal: Ann Am Thorac Soc. 2019 Mar 25. doi: 10.1513/AnnalsATS.201809-601OC. [Epub ahead of print] Abstract: RATIONALE: […]
In a just-published piece in Chest as part of the journal’s “Giants in Chest Medicine” series, Joel Kline, MD, and Joseph Zabner, MD, offer an incredible anecdote about Donald C. Zavala, MD, FCCP, Professor Emeritus of Internal Medicine and the department’s first fellow in pulmonary medicine, “at a time,” they write, “when chest physicians primarily focused on [tuberculosis].” […]
Article: Is Homoarginine a Protective Cardiovascular Risk Factor? Authors: Ekaterina S. Karetnikova, Natalia Jarzebska, Alexander G. Markov, Norbert Weiss, Steven R. Lentz, Roman N. Rodionov Journal: Arterioscler Thromb Vasc Biol. 2019 Mar 14:ATVBAHA118312218 Abstract: A series of recent epidemiological studies have implicated the endogenous nonproteinogenic amino acid l-homoarginine as a novel candidate cardiovascular risk factor. […]
Article: Nutrient Composition Comparison between the Low Saturated Fat Swank Diet for Multiple Sclerosis and Healthy U.S.-Style Eating Pattern Authors: Catherine A. Chenard, Linda M. Rubenstein, Linda G. Snetselaar, and Terry L. Wahls Journal: Nutrients. 2019 Mar 13;11(3). pii: E616 Abstract: Multiple sclerosis (MS) is an incurable degenerative disease that attacks the central nervous system. […]
Article: Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron Authors: Jonathan Cedernaes, Wenyu Huang, Kathryn Moynihan Ramsey, Nathan Waldeck, Lei Cheng, Biliana Marcheva, Chiaki Omura, Yumiko Kobayashi, Clara Bien Peek, Daniel C. Levine, Ravindra Dhir, Raj Awatramani, Christopher A. Bradfield, Xiaozhong A. Wang, Joseph S. Takahashi, Mohamad Mokadem, Rexford S. […]
Article: Angiotensin II-induced Hypertension and Cardiac Hypertrophy are Differentially Mediated by TLR3- and TLR4-Dependent Pathways Authors: Madhu V. Singh, Michael Z. Cicha, Sarah Nunez, David K. Meyerholz, Mark W. Chapleau, Francois M. Abboud Journal: Am J Physiol Heart Circ Physiol. 2019 Feb 22. doi: 10.1152/ajpheart.00697.2018. [Epub ahead of print] Abstract: Toll-like receptors (TLR) are key […]
Loreen Herwaldt, MD, professor in Infectious Diseases and of Epidemiology, and Priyadarshini Pennathur, PhD, assistant professor in Industrial and Systems Engineering, presented an invited talk on personal protective equipment (PPE) design problems to a standing committee within the National Academies of Sciences, Engineering, and Medicine. The committee is tasked with, in part, addressing topics that […]
Article: Regulation of cardiac transcription by thyroid hormone and Med13 Authors: Rachel A. Minerath, Colleen M. Dewey, Duane D. Hall, Chad E. Grueter Journal: J Mol Cell Cardiol. 2019 Feb 12;129:27-38 Abstract: Thyroid hormone (TH) is a key regulator of transcriptional homeostasis in the heart. While hypothyroidism is known to result in adverse cardiac effects, […]
The genetic disorder Duchenne muscular dystrophy (DMD) occurs when there is a lack of the protein dystrophin, causing progressively weak muscle development in children and a shorter life span. Once children begin steroid treatment, their bones become very fragile and experience delays in growth. Dual X-ray absorptiometry, or DXA scans, which are used to monitor […]
Acute injuries of the kidney, which cause temporary loss of kidney function, were believed to be harmless and the kidneys could make a full recovery following these episodes. However, more research revealed that any insult to the kidneys sets up a slow loss of functional nephrons and progressive formation of fibrotic scars. Massimo Attanasio, MD, […]