Article: The Effects of Timed Light Exposure in Critically Ill Patients: A Randomized Controlled Pilot Study
Authors: Brian K. Gehlbach, Shruti B Patel, Eve Van Cauter, Anne S Pohlman, Jesse B. Hall, and Joseph Zabner
Journal: Am J Respir Crit Care Med. 2018 Mar 12
Keywords: circadian rhythm; critical illness; light therapy; melatonin; sleep
The circadian timing system aligns genetic, physiologic, and behavioral rhythms to solar time. The master pacemaker of the body is normally synchronized, or entrained, to solar time each day by environmental zeitgebers (“time givers”), particularly the light-dark cycle. When sleep is mistimed with relationship to the endogenous circadian rhythm, the circadian regulation of the human transcriptome is disrupted, and health is adversely affected.
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