Polarized AAVR expression determines infectivity by AAV gene therapy vectors

Article: Polarized AAVR expression determines infectivity by AAV gene therapy vectors Authors: Bradley A. Hamilton, Xiaopeng Li, Alejandro A. Pezzulo, Mahmoud H. Abou Alaiwa & Joseph Zabner Journal: Gene Therapy volume 26, pages240–249 (2019) Abstract: Adeno-associated virus (AAV) has been investigated to transfer the cystic fibrosis transmembrane conductance regulator (CFTR) to airways. Inhaled AAV2-CFTR in […]

Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells

Article: Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells Authors: Shelby C. Bearrows, Casey J. Bauchle, McKenzie Becker, Jonathan M. Haldeman, Svetha Swaminathan, Samuel B. Stephens Journal: J Cell Sci. 2019 Jul 1;132(13) Abstract: Chromogranin B (CgB, also known as CHGB) is abundantly expressed in dense core secretory granules […]

Coronary Spasm and Polymorphic Ventricular Tachycardia One Year After Takotsubo

Article: Coronary Spasm and Polymorphic Ventricular Tachycardia One Year After Takotsubo Authors: Noah N. Williford MD, Alexander Mazur MD, Troy Rhodes MD, PhD, Elaine Demetroulis MD, Milena A. Gebska MD, PhD Journal: Mayo Clin Proc Innov Qual Outcomes. 2019 Jun; 3(2): 231–234. Abstract: Stress cardiomyopathy is typically considered to be a disease with a favorable […]

Tau interacts with SHP2 in neuronal systems and in Alzheimer’s disease

Article: Tau interacts with SHP2 in neuronal systems and in Alzheimer’s disease Authors: Yohan Kim, Guanghao Liu, Chad J. Leugers, Joseph D. Mueller, Meghan B. Francis, Marco M. Hefti, Julie A. Schneider, Gloria Lee Journal: J Cell Sci. 2019 Jun 14. pii: jcs.229054. doi: 10.1242/jcs.229054. [Epub ahead of print] Abstract: Microtubule-associated protein tau, an integral […]

Renal Denervation and CD161a Immune Ablation Prevent Cholinergic Hypertension and Renal Sodium Retention

Article: Renal Denervation and CD161a Immune Ablation Prevent Cholinergic Hypertension and Renal Sodium Retention Authors: Nandita S Raikwar, Cameron Braverman, Peter M. Snyder, Robert A. Fenton, David K. Meyerholz, Francois M. Abboud, and Sailesh C. Harwani Journal: Am J Physiol Heart Circ Physiol. 2019 Jun 7. doi: 10.1152/ajpheart.00234.2019. [Epub ahead of print] Abstract: RATIONALE: Cholinergic […]

Preliminary findings from a concise emergency department model to predict anaphylaxis and develop a clinical decision support tool

Article: Preliminary findings from a concise emergency department model to predict anaphylaxis and develop a clinical decision support tool Authors: Sangil Lee MD, MS, Cassandra Hardy BS, Morgan Bobb Swanson BS, Karisa Harland MPH, PhD, Azeemuddin Ahmed MD, MBA and Zuhair Ballas MD Journal: J Allergy Clin Immunol Pract. 2019 Apr 9. pii: S2213-2198(19)30373-3. doi: […]

Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children: Prevalence, Predictors of Survival, and Implications for Hospital Profiling

Article: Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children: Prevalence, Predictors of Survival, and Implications for Hospital Profiling Authors: Rohan Khera, Yuanyuan Tang, Saket Girotra, Vinay M. Nadkarni, Mark S. Link, Tia T. Raymond, Anne-Marie Guerguerian, Robert A. Berg, and Paul S. Chan Journal: Circulation. 2019 Apr 22. doi: 10.1161/CIRCULATIONAHA.118.039048. [Epub ahead […]

Ultrasound-guided vascular access in critical illness

Article: Ultrasound-guided vascular access in critical illness Authors: Schmidt GA, Blaivas M, Conrad SA, Corradi F, Koenig S, Lamperti M, Saugel B, Schummer W, Slama M Journal: Intensive Care Med. 2019 Apr;45(4):434-446 Abstract: Over the past two decades, ultrasound (US) has become widely accepted to guide safe and accurate insertion of vascular devices in critically […]