Risk of Venous Thromboembolism in Hospitalized Patients with Acute Ischemic Stroke Versus Other Neurological Conditions

Article: Risk of Venous Thromboembolism in Hospitalized Patients with Acute Ischemic Stroke Versus Other Neurological Conditions Authors: Aayushi Garg, Nirav Dhanesha, Amir Shaban, Edgar A Samaniego, Anil K Chauhan, Enrique C Leira Journal: J Stroke Cerebrovasc Dis. 2021 Nov;30(11):106077 Abstract: Background: The mechanism of increased risk of venous thromboembolism (VTE) after acute ischemic stroke (AIS) […]

Relabeling of penicillin drug allergy after evaluation in a drug allergy clinic

Article: Relabeling of penicillin drug allergy after evaluation in a drug allergy clinic Authors: Deanna McDanel, Lyvia Hosch, Kassi D Pham, Abbey Schwery, Karlie Seiler, Amy M Dowden Journal: J Allergy Clin Immunol Pract. 2021 Sep 16;S2213-2198(21)01004-7 Clinical implications: More than 90% of patients after evaluation in a drug allergy clinic had their penicillin allergy […]

Altering Early Life Gut Microbiota Has Long-Term Effect on Immune System and Hypertension in Spontaneously Hypertensive Rats

Article: Altering Early Life Gut Microbiota Has Long-Term Effect on Immune System and Hypertension in Spontaneously Hypertensive Rats Authors: Francois M. Abboud, Michael Z. Cicha, Aaron Ericsson, Mark W. Chapleau, and Madhu V. Singh Journal: Front. Physiol., 29 October 2021 Abstract: Hypertension is regulated by immunological components. Spontaneously hypertensive rats (SHR) display a large population […]

Central venous-to-arterial PCO2 difference as a marker to identify fluid responsiveness in septic shock

Article: Central venous-to-arterial PCO2 difference as a marker to identify fluid responsiveness in septic shock Authors: Boulos Nassar, Mohamed Badr, Nicolas Van Grunderbeeck, Johanna Temime, Florent Pepy, Gaelle Gasan, Laurent Tronchon, Didier Thevenin & Jihad Mallat Journal: Sci Rep 11, 17256 (2021) Abstract: Defining the hemodynamic response to volume therapy is integral to managing critically […]

Intratumoral talimogene laherparepvec injection with concurrent preoperative radiation in patients with locally advanced soft-tissue sarcoma of the trunk and extremities: phase IB/II trial

Article: Intratumoral talimogene laherparepvec injection with concurrent preoperative radiation in patients with locally advanced soft-tissue sarcoma of the trunk and extremities: phase IB/II trial Authors: Varun Monga, Benjamin J Miller, Munir Tanas, Sarag Boukhar, Bryan Allen, Carryn Anderson, Laura Stephens, Stacey Hartwig, Steven Varga, Jon Houtman, Lei Wang, Weizhou Zhang, Omar Jaber, Jon Thomason, David […]

Utility of high resolution mapping to guide ablation of ventricular arrhythmias from the aortic sinuses of Valsalva

Article: Utility of high resolution mapping to guide ablation of ventricular arrhythmias from the aortic sinuses of Valsalva Authors: Faisal Matto, Dev Venugopal, Prashant D Bhave, Troy E Rhodes, Alexander Mazur Journal: J Interv Card Electrophysiol. 2021 Aug 7. doi: 10.1007/s10840-021-01040-9. Online ahead of print. Abstract: Purpose: Left ventricular outflow tract (LVOT) arrhythmias are commonly […]

Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function

Article: Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function Authors: Casey J Bauchle, Kristen E Rohli, Cierra K Boyer, Vidhant Pal, Jonathan V Rocheleau, Siming Liu, Yumi Imai, Eric B Taylor, Samuel B Stephens Journal: Diabetes. 2021 Aug;70(8):1717-1728 Abstract: The defining feature of pancreatic islet […]

PKM2 promotes neutrophil activation and cerebral thrombo-inflammation: Therapeutic implications for ischemic stroke

Article: PKM2 promotes neutrophil activation and cerebral thrombo-inflammation: Therapeutic implications for ischemic stroke Authors: Nirav Dhanesha, Rakesh B Patel, Prakash Doddapattar, Madankumar Ghatge, Gagan D Flora, Manish Jain, Daniel Thedens, Heena Olalde, Mariia Kumskova, Enrique Leira, Anil K Chauhan Journal: Blood. 2021 Sep 15;blood.2021012322. doi: 10.1182/blood.2021012322. Online ahead of print. Abstract: There is a critical […]

Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer

Article: Prospective correlation between the patient microbiome with response to and development of immune-mediated adverse effects to immunotherapy in lung cancer Authors: Justin Chau, Meeta Yadav, Ben Liu, Muhammad Furqan, Qun Dai, Shailesh Shahi, Arnav Gupta, Keri Nace Mercer, Evan Eastman, Taher Abu Hejleh , Carlos Chan, George J Weiner, Catherine Cherwin, Sonny T M […]

Individualized coaching in health system-wide provider communication training

Article: Individualized coaching in health system-wide provider communication training Authors: Kipton Pedersen, Theresa M H Brennan, Alexander D Nance, Marcy E Rosenbaum Journal: Patient Educ Couns. 2021 Jun 30;S0738-3991(21)00422-5. doi: 10.1016/j.pec.2021.06.023. Online ahead of print. Abstract: Objectives: Most practicing health professionals lack communication skills training (CST). Increasingly health care systems have implemented CST programs, mainly […]