Recent insights on the use of topical steroids in eosinophilic esophagitis

Article: Recent insights on the use of topical steroids in eosinophilic esophagitis Authors: Aditi Reddy, Divya Ashat, Arvind R Murali Journal: Expert Rev Gastroenterol Hepatol. 2020 Jul 7;1-11. Abstract:Introduction: Eosinophilic Esophagitis (EoE) is an immune-mediated, chronic inflammatory disorder of the esophagus. Topical steroids have been used in the management of EoE for over 15 years. […]

Transformational Changes Between Non-Small Cell and Small Cell Lung Cancer-Biological and Clinical Relevance-A Review

Article: Transformational Changes Between Non-Small Cell and Small Cell Lung Cancer-Biological and Clinical Relevance-A Review Authors: Gerald Clamon, William Zeitler, Josiah An, Taher A Hejleh Journal: Am J Clin Oncol. 2020 Jun 5. doi: 10.1097/COC.0000000000000720. Online ahead of print Abstract:During the course of therapy, patients with small cell lung cancer have been noted to develop transformation […]

Lung Cancer Screening with Low-Dose CT: a Meta-Analysis

Article: Lung Cancer Screening with Low-Dose CT: a Meta-Analysis Authors: Richard M Hoffman, Rami P Atallah, Roger D Struble, Robert G Badgett Journal: J Gen Intern Med. 2020 Jun 24. doi: 10.1007/s11606-020-05951-7. Online ahead of print. Abstract: Background: Randomized controlled trials have evaluated the efficacy of low-dose CT (LDCT) lung cancer screening on lung cancer […]

Munc13 mediates klotho-inhibitable diacylglycerol-stimulated exocytotic insertion of pre-docked TRPC6 vesicles

Article: Munc13 mediates klotho-inhibitable diacylglycerol-stimulated exocytotic insertion of pre-docked TRPC6 vesicles Authors: Jian Xie, Sung-Wan An, Xin Jin, Yuan Gui, Chou-Long Huang Journal: PLoS One. 2020 Mar 5;15(3):e0229799. Abstract: α-Klotho is a type 1 transmembrane protein that exhibits aging suppression function. The large amino-terminal extracellular domain of α-klotho is shed as soluble klotho (sKlotho) and […]

Randomized controlled trial comparing the Franseen needle with a Fork-tip needle for EUS-guided fine-needle biopsy

Article: Randomized controlled trial comparing the Franseen needle with a Fork-tip needle for EUS-guided fine-needle biopsy Authors: Munish Ashat, Jagpal S Klair, Sydney L Rooney, Sagar J Vishal, Chris Jensen, Arvind R Murali, Nadav Sahar, Rami El-Abiad, Henning Gerke Journal: Gastrointest Endosc. 2020 Jun 8;S0016-5107(20)34407-2 Abstract: Background and aims: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) primarily […]

Non-Conventional Treatments for Conventional Chondrosarcoma

Article: Non-Conventional Treatments for Conventional Chondrosarcoma Authors: Varun Monga, Hariharasudan Mani, Angela Hirbe, Mohammed Milhem Journal: Cancers (Basel). 2020 Jul 19;12(7):E1962 Abstract: Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic […]

High dose trivalent influenza vaccine compared to standard dose vaccine in patients with rheumatoid arthritis receiving TNF-alpha inhibitor therapy and healthy controls: Results of the DMID 10-0076 randomized clinical trial

Article: High dose trivalent influenza vaccine compared to standard dose vaccine in patients with rheumatoid arthritis receiving TNF-alpha inhibitor therapy and healthy controls: Results of the DMID 10-0076 randomized clinical trial Authors: Jack T Stapleton, Nancy Wagner, Rebecca Tuetken, Abbie R Bellamy, Heather Hill, Sonnie Kim, Patricia L Winokur Journal: Vaccine. 2020 May 13;38(23):3934-3941 Abstract: […]

Eating Pattern and Nutritional Risks among People with Multiple Sclerosis Following a Modified Paleolithic Diet

Article: Eating Pattern and Nutritional Risks among People with Multiple Sclerosis Following a Modified Paleolithic Diet Authors: Tyler J. Titcomb, Babita Bisht, David D. Moore, III, Yashpal S. Chhonker, Daryl J. Murry, Linda G. Snetselaar, and Terry L. Wahls Journal: Nutrients. 2020 Jun 20;12(6):1844 Abstract: Preliminary studies suggest that a modified Paleolithic diet may benefit […]

Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation

Article: Targeting Myeloid-Specific Integrin α9β1 Improves Short- and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis and Inflammation Authors: Nirav Dhanesha, Manish Jain, Amit K. Tripathi, Prakash Doddapattar, Mehul Chorawala, Girish Bathla, Manasa K. Nayak, Madankumar Ghatge, Steven R. Lentz, Shigeyuki Kon, Anil K. Chauhan Journal: Circ Res. 2020 Jun 5;126(12):1779-1794. […]

Inhibition of Protein Kinase C Beta Phosphorylation Activates Nuclear Factor-Kappa B and Improves Postischemic Recovery in Type 1 Diabetes

Article: Inhibition of Protein Kinase C Beta Phosphorylation Activates Nuclear Factor-Kappa B and Improves Postischemic Recovery in Type 1 Diabetes Authors: Satyanarayana Alleboina, Thomas Wong, Madhu V Singh, Ayotunde O Dokun Journal: Exp Biol Med (Maywood). 2020 May;245(9):785-796. doi: 10.1177/1535370220920832. Epub 2020 Apr 23. Abstract:Peripheral artery disease (PAD) is a major health problem and is […]