A tale of two peripheral blood CD34+ cell counts: Evaluation of unexpectedly high values prior to peripheral stem cell collection

Article: A tale of two peripheral blood CD34+ cell counts: Evaluation of unexpectedly high values prior to peripheral stem cell collection Authors: Kai J Rogers, Meredith G Parsons, Christopher S Strouse, Umar Farooq, Annette J Schlueter Journal: Transfus Apher Sci. 2022 Dec 14;103624 Excerpt: Hematopoietic stem cells (HSCs) form the foundation of treatment for many […]

Alpha-1-Antitrypsin Pi*MZ variant increases risk of developing hepatic events in nonalcoholic fatty liver disease patients

Article: Alpha-1-Antitrypsin Pi*MZ variant increases risk of developing hepatic events in nonalcoholic fatty liver disease patients Authors: Arvind R Murali, Sameer Prakash, Antonio J Sanchez Journal: Clin Res Hepatol Gastroenterol. 2022 Dec 9;47(2):102066 Abstract: Aims: Heterozygous alpha-1-antitrypsin (A1AT) Pi*MZ variant has been shown to increase the risk of developing liver cirrhosis in patients with non-alcoholic […]

Brain Fog and Fatigue following COVID-19 Infection: An Exploratory Study of Patient Experiences of Long COVID

Article: Brain Fog and Fatigue following COVID-19 Infection: An Exploratory Study of Patient Experiences of Long COVID Authors: Emily E Chasco, Kimberly Dukes, DeShauna Jones, Alejandro P Comellas, Richard M Hoffman, Alpana Garg Journal: Int J Environ Res Public Health. 2022 Nov 23;19(23):15499 Abstract: Post-acute sequelae of SARS-CoV-2 (PASC) is a poorly understood condition with […]

The Rapid Reduction of Infection-Related Visits and Antibiotic Use Among People With Cystic Fibrosis After Starting Elexacaftor-Tezacaftor-Ivacaftor

Article: The Rapid Reduction of Infection-Related Visits and Antibiotic Use Among People With Cystic Fibrosis After Starting Elexacaftor-Tezacaftor-Ivacaftor Authors: Aaron C Miller, Logan M Harris, Joseph E Cavanaugh, Mahmoud Abou Alaiwa, David A Stoltz, Douglas B Hornick, Philip M Polgreen Journal: Clin Infect Dis. 2022 Sep 30;75(7):1115-1122 Abstract: Background: People with cystic fibrosis (CF) routinely […]

Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models?

Article: Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models? Author: Mark Yorek Journal: Curr Diabetes Rev. 2022;18(5):e040521193121 Abstract: Introduction: Animal models have been widely used to investigate the etiology and potential treatments for diabetic peripheral neuropathy. What we have learned from these studies and the extent to which this information has […]

Discussion and Initiation of HIV Pre-exposure Prophylaxis Were Rare Following Diagnoses of Sexually Transmitted Infections Among Veterans

Article: Discussion and Initiation of HIV Pre-exposure Prophylaxis Were Rare Following Diagnoses of Sexually Transmitted Infections Among Veterans Authors: Takaaki Kobayashi, Puja Van Epps, Marissa M Maier, Lauren A Beste, Brice F Beck, Bruce Alexander, Michael E Ohl Journal: J Gen Intern Med. 2022 Aug;37(10):2482-2488 Abstract: Background: Healthcare encounters for the diagnosis and treatment of […]

Sex-Specific Differences in Endothelial Function Are Driven by Divergent Mitochondrial Ca2+ Handling

Article: Sex-Specific Differences in Endothelial Function Are Driven by Divergent Mitochondrial Ca2+ Handling Authors: Celio Damacena de Angelis, Benney T Endoni, Daniel Nuno, Kathryn Lamping, Johannes Ledolter, Olha M Koval, Isabella M Grumbach Journal: J Am Heart Assoc. 2022 Jul 5;11(13):e023912 Abstract: Background Sex-specific differences in vasodilation are mediated in part by differences in cytosolic […]

Oxidative stress contributes to reductions in microvascular endothelial- and nitric oxide-dependent dilation in women with a history of gestational diabetes

Article: Oxidative stress contributes to reductions in microvascular endothelial- and nitric oxide-dependent dilation in women with a history of gestational diabetes Authors: Anna E Stanhewicz, Rowan L Schlarmann, Kaila M Brustkern, Diana I Jalal Journal: J Appl Physiol (1985). 2022 Aug 1;133(2):361-370. Abstract: Women with a history of gestational diabetes mellitus (GDM) are twice as likely to develop […]

Leadership Diversity and Development in the Nation’s Cancer Centers

Article: Leadership Diversity and Development in the Nation’s Cancer Centers Authors: Caryn Lerman, Chanita Hughes-Halbert, Mary Falcone, David M Gosky, Roy A Jensen, Kelvin P Lee, Edith Mitchell, Kunle Odunsi, Jennifer W Pegher, Elisa Rodriguez, Yolanda Sanchez, Reuben Shaw, George Weiner, Cheryl L Willman Journal: J Natl Cancer Inst. 2022 Sep 9;114(9):1214-1221 Abstract: The capacity […]

Monogenic focal segmental glomerulosclerosis: A conceptual framework for identification and management of a heterogeneous disease

Article: Monogenic focal segmental glomerulosclerosis: A conceptual framework for identification and management of a heterogeneous disease Authors: Meenakshi Sambharia, Prerna Rastogi, Christie P Thomas Journal: Am J Med Genet C Semin Med Genet. 2022 Sep;190(3):377-398 Abstract: Focal segmental glomerulosclerosis (FSGS) is not a disease, rather a pattern of histological injury occurring from a variety of […]