Avacopan: An Oral Complement 5a Inhibitor for ANCA-associated Vasculitis

Article: Avacopan: An Oral Complement 5a Inhibitor for ANCA-associated Vasculitis Authors: Matthew J Mandell, Gatr-Alnada Gheriani, Aleksander Lenert, Petar S Lenert Journal: touchREVIEWS in RMD 2022;1(1):Online ahead of publication Abstract: The oral complement 5a receptor antagonist, avacopan, was recently studied in phase II and III clinical trials in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis […]

Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis

Article: Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis Authors: Prakash Doddapattar, Rishabh Dev, Madankumar Ghatge, Rakesh B Patel, Manish Jain, Nirav Dhanesha, Steven R Lentz, Anil K Chauhan Journal: Circ Res. 2022 Apr 29;130(9):1289-1305 Abstract: Background: The glycolytic enzyme PKM2 (pyruvate kinase muscle 2) is upregulated in monocytes/macrophages of patients with atherosclerotic coronary […]

Association of Nonobstructive Chronic Bronchitis With All-Cause Mortality

Article: Association of Nonobstructive Chronic Bronchitis With All-Cause Mortality Authors: Spyridon Fortis, MD, Zacariah K. Shannon, DC, Crystal J. Garcia, Rodrigo Vazquez Guillamet, MD, Ariel M. Aloe, PhD, Marin L. Schweizer, PhD, Victor Kim, MD, Rajeshwari Nair, PhD Journal: Chest. 2022 DOI:https://doi.org/10.1016/j.chest.2022.02.003 Abstract: Background: The effect of nonobstructive chronic bronchitis (CB) on mortality is unclear. […]

Perceptions of risk of SARS-CoV-2 transmission in social and educational activities by infectious diseases and general pediatric healthcare providers, a pre-vaccine risk perception cross-sectional survey

Article: Perceptions of risk of SARS-CoV-2 transmission in social and educational activities by infectious diseases and general pediatric healthcare providers, a pre-vaccine risk perception cross-sectional survey Authors: Andrew B Janowski, Philip M Polgreen, Susan E Beekmann, Jason G Newland Journal: PLoS One. 2022 Feb 11;17(2):e0263767 Abstract: Background: The perception of the transmission risks of SARS-CoV-2 […]

TREM-1 is required for enhanced OpZ-induced superoxide generation following priming

Article: TREM-1 is required for enhanced OpZ-induced superoxide generation following priming Authors: Shubha Murthy, Sankar Baruah, Jayden L Bowen, Kathy Keck, Brett A Wagner, Garry R Buettner, David B Sykes, Julia Klesney-Tait Journal: J Leukoc Biol. 2022 Jan 24. doi: 10.1002/JLB.3A0421-212R. Online ahead of print. Abstract: Inflammatory agents, microbial products, or stromal factors pre-activate or […]

The Role of Clinical Features and Serum Biomarkers in Identifying Patients with Incomplete Lupus Erythematosus at Higher Risk of Transitioning to Systemic Lupus Erythematosus: Current Perspectives

Article: The Role of Clinical Features and Serum Biomarkers in Identifying Patients with Incomplete Lupus Erythematosus at Higher Risk of Transitioning to Systemic Lupus Erythematosus: Current Perspectives Authors: Erin Sternhagen, Brittany Bettendorf, Aleksander Lenert, Petar S Lenert Journal: J Inflamm Res. 2022 Feb 18;15:1133-1145. Abstract: Discovery of antinuclear antibodies (ANA) enabled earlier diagnosis of systemic […]

Patient Characteristics and Survival Outcomes of Non-Metastatic, Non-Clear Cell Renal Cell Carcinoma

Article: Patient Characteristics and Survival Outcomes of Non-Metastatic, Non-Clear Cell Renal Cell Carcinoma Authors: Josiah An, Vignesh T Packiam, Adithya Chennamadhavuni, Jordan Richards, Jayanshu Jain, Sarah L Mott, Rohan Garje Journal: Front Oncol. 2022 Jan 10;11:786307 Abstract: Background: Non-clear cell renal cell carcinoma (ccRCC) includes histologically and molecularly distinct subtypes such as papillary, chromophobe, collecting […]

Pulmonary Aspects of COVID-19

Article: Pulmonary Aspects of COVID-19 Authors: Kevin C Doerschug, Gregory A Schmidt Journal: Annu Rev Med. 2022 Jan 27;73:81-93 Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory virus that gains entry via angiotensin-converting enzyme 2 (ACE2) within airway epithelium. Patients exhibit a spectrum of respiratory symptoms from asymptomatic to respiratory failure. Patient […]

Leveraging implementation science to advance antibiotic stewardship practice and research

Article: Leveraging implementation science to advance antibiotic stewardship practice and research Authors: Daniel J Livorsi, Mari-Lynn Drainoni, Heather Schacht Reisinger, Neha Nanda, Jessina C McGregor, Tamar F Barlam, Andrew M Morris, Julia E Szymczak Journal: Infect Control Hosp Epidemiol. 2022 Feb;43(2):139-146 Excerpt: Antibiotics are among the most commonly prescribed medications, and there is evidence to […]