Article: IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca2+ Homeostasis Authors: Qian Shi, Jinxi Wang, Hamza Malik, Xuguang Li, Jennifer Streeter, Jacob Sharafuddin, Eric Weatherford, David Stein, Yuval Itan, Biyi Chen, Duane Hall, Long-Sheng Song, E Dale Abel Journal: Circulation. 2024 Dec 10;150(24):1966-1983 Abstract: Background: The docking protein IRS2 (insulin receptor substrate protein-2) is […]
Article: IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption Authors: Guillermo S Romano Ibarra, Lei Lei, Wenjie Yu, Andrew L Thurman, Nicholas D Gansemer, David K Meyerholz, Alejandro A Pezzulo, Paul B McCray, Ian M Thornell, David A Stoltz Journal: J Clin Invest. 2024 Sep 10;134(21):e181995 Abstract: The airway surface […]
Article: Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial Authors: Andreia Morais, Takahiko Imai, Xuyan Jin, Joseph J Locascio, Ligia Boisserand, Alison L Herman, Anjali Chauhan, Jessica Lamb, Karisma Nagarkatti , Marcio A Diniz, Mariia Kumskova, Nirav Dhanesha, Pradip K Kamat, Mohammad Badruzzaman Khan, Krishnan M Dhandapani, Rakesh B […]
Article: Spectrum of inflammatory manifestations in patients with nucleotide-binding oligomerization domain containing 2 high-risk alleles Authors: Michell M Lozano-Chinga, Madalyn Walsh, Brooke Harrison, Zuhair K Ballas Journal: Ann Allergy Asthma Immunol. 2024 Aug 22:S1081-1206(24)00530-1 Excerpt: Nucleotide-binding oligomerization domain containing 2 (NOD2) is a member of the N-terminal caspase recruitment domains that functions as an intracellular […]
Article: Comparing Federal Communications Commission and Microsoft Estimates of Broadband Access for Mental Health Video Telemedicine Among Veterans: Retrospective Cohort Study Authors: Amy MJ O’Shea, Kailey Mulligan, Knute D Carter, Bjarni Haraldsson, Charlie M Wray, Ariana Shahnazi, Peter J Kaboli Journal: J Med Internet Res. 2024 Aug 8:26:e47100 Abstract: Background: The COVID-19 pandemic highlighted the […]
Article: Fibroblast growth receptor 1 is regulated by G-quadruplex in metastatic breast cancer Authors: Hang Lin, Muhammad Hassan Safdar, Sarah Washburn, Saeed S Akhand, Jonathan Dickerhoff, Mitchell Ayers, Marvis Monteiro, Luis Solorio, Danzhou Yang, Michael K Wendt Journal: Commun Biol. 2024 Aug 9;7(1):963 Abstract: Limiting cellular plasticity is of key importance for the therapeutic targeting […]
Article: Precision Medicine Hinges On Access To Genetic Counselors Author: Colleen Campbell Journal: Health Affairs Forefront, October 22, 2024. DOI: 10.1377/forefront.20241018.271264 Excerpt: The Food and Drug Administration’s approval of nearly a dozen gene therapies in the past year, including milestone treatments for sickle cell disease and hemophilia B, has finally ushered in the era of […]
Article: Il-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption Authors: Guillermo S Romano Ibarra, Lei Lei, Wenjie Yu, Andrew L Thurman, Nicholas D Gansemer, David K Meyerholz, Alejandro A Pezzulo, Paul B McCray, Ian M Thornell, David A Stoltz Journal: J Clin Invest. 2024 Sep 10:e181995. doi: 10.1172/JCI181995. Online ahead […]
Article: Ultra-low dose hip CT-based automated measurement of volumetric bone mineral density at proximal femoral subregions Authors: Xiaoliu Zhang, Syed Ahmed Nadeem, Paul A DiCamillo, Amal Shibli-Rahhal, Elizabeth A Regan, R Graham Barr, Eric A Hoffman, Alejandro P Comellas, Punam K Saha Journal: Med Phys. 2024 Jul 23. doi: 10.1002/mp.17319 Abstract: Background: Forty to fifty […]
Article: Genetic ablation of myeloid integrin α9 attenuates early atherosclerosis Authors: Tarun Barbhuyan, Rakesh B Patel, Ivan Budnik, Anil K Chauhan Journal: J Leukoc Biol. 2024 Jul 22:qiae161. doi: 10.1093/jleuko/qiae161. Abstract: Integrin α9β1 is known to stabilize leukocyte adhesion to the activated endothelium. We determined the role of myeloid cell α9β1 in early atherosclerosis in […]