Article: PRMT5 Inhibition Hits a Nerve (Sheath Tumor): A Targeted Strategy for MPNSTs

Authors: Alexa P Sheehan, Akshaya Warrier, Rebecca D Dodd

Journal: Clin Cancer Res. 2025 Nov 14;31(22):4620-4622

Abstract:
Protein arginine methyltransferase 5 inhibitors represent a promising therapeutic approach for multiple cancers, but their clinical development is hindered by toxicity to normal cells. Synthetic lethality approaches using MTAP-cooperative protein arginine methyltransferase 5 inhibitors offer a compelling strategy that selectively targets cancer cells in nerve sheath sarcomas and other MTAP-deleted tumors. See related article by Zhang et al., p. 4779.

Link to journal online: https://aacrjournals.org/clincancerres/article/31/22/4620/767059/PRMT5-Inhibition-Hits-a-Nerve-Sheath-Tumor-A