Article: Lipid Droplets’ Role in the Regulation of β-Cell Function and β-Cell Demise in Type 2 Diabetes Authors: Xin Tong, Siming Liu, Roland Stein, Yumi Imai Journal: Endocrinology. 2022 Mar 1;163(3):bqac007 Abstract: During development of type 2 diabetes (T2D), excessive nutritional load is thought to expose pancreatic islets to toxic effects of lipids and reduce […]
Article: Pulmonary Aspects of COVID-19 Authors: Kevin C Doerschug, Gregory A Schmidt Journal: Annu Rev Med. 2022 Jan 27;73:81-93 Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory virus that gains entry via angiotensin-converting enzyme 2 (ACE2) within airway epithelium. Patients exhibit a spectrum of respiratory symptoms from asymptomatic to respiratory failure. Patient […]
Article: Leveraging implementation science to advance antibiotic stewardship practice and research Authors: Daniel J Livorsi, Mari-Lynn Drainoni, Heather Schacht Reisinger, Neha Nanda, Jessina C McGregor, Tamar F Barlam, Andrew M Morris, Julia E Szymczak Journal: Infect Control Hosp Epidemiol. 2022 Feb;43(2):139-146 Excerpt: Antibiotics are among the most commonly prescribed medications, and there is evidence to […]
Survival rates for in-hospital cardiac arrests (IHCA) have plateaued at 25% in recent years. With nearly 290,000 people affected by IHCA each year, researchers aim to identify whether incidence of IHCA varies across hospitals in the United States, a key first step towards identifying best practices. Tyler Rasmussen, MD, PhD, Internal Medicine Chief Fellow in […]
Article: Atypical Large Vessel Vasculitis Presenting With Cholestatic Liver Abnormalities: Case-Based Review Authors: Sameet Sangha, Aleksander Lenert, Salma Dawoud, Aneet Kaur, Hasan Yazan, Michael D Voigt, Petar Lenert Journal: J Clin Rheumatol. 2021 Dec 1;27(8):e561-e567. Abstract: Clinicians usually easily recognize cranial manifestations of giant cell arteritis (GCA) such as new-onset headache, jaw claudication, scalp tenderness, […]
Article: Optimization of RNA Aptamer SELEX Methods: Improved Aptamer Transcript 3′-End Homogeneity, PAGE Purification Yield, and Target-Bound Aptamer RNA Recovery Authors: Chandan Narayan, Suresh Veeramani, William H Thiel Journal: Nucleic Acid Ther. 2022 Feb;32(1):74-80. Abstract: Since its inception in the early 1990s, SELEX remains the gold standard for discovering RNA aptamers specific for proteins and […]
Though the collection’s actual final poem is one he dictated by phone from his hospice bed, the last poem that Dick Stahl wrote on his own with pen to legal pad, “Life, Loving and Living,” closes with these words: “I want the last words in this book to include / what we all aspire to—a […]
Article: Hospital Variation in Non-Invasive Ventilation Use for Acute Respiratory Failure Due to COPD Exacerbation Authors: Spyridon Fortis, Yubo Gao, Amy M J O’Shea, Brice Beck, Peter Kaboli, Mary Vaughan Sarrazin Journal: Int J Chron Obstruct Pulmon Dis. 2021 Nov 17;16:3157-3166. Abstract: Background: Non-invasive mechanical ventilation (NIV) use in patients admitted with acute respiratory failure […]
Article: Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects Authors: Marwa Abu El Haija, Yuanchao Ye, Yi Chu, Hussein Herz, Benjamin Linden, Shailesh K Shahi, Kasra Zarei, Ashutosh K Mangalam, Steven J Mcelroy, Mohamad Mokadem Journal: Surg Obes Relat Dis. 2021 Dec;17(12):1996-2006 Abstract: Background: Toll-like receptor 4 (TLR4) […]
Article: Neutrophil-derived extracellular vesicles modulate the phenotype of naïve human neutrophils Authors: Maya F Amjadi, Benjamin S Avner, Mallary C Greenlee-Wacker, Alexander R Horswill, William M Nauseef Journal: J Leukoc Biol. 2021 Nov;110(5):917-925. Abstract: Neutrophils (PMN) regulate inflammation in many ways, including communication with other immune cells via extracellular vesicles (EVs). EVs released by human […]