Article: Proinflammatory Cytokines Mediate Pancreatic β-Cell-Specific Alterations to Golgi Integrity via iNOS-Dependent Mitochondrial Inhibition Authors: Sandra E Blom, Palin R Narsian, Riley M Behan-Bush, James A Ankrum, Ling Yang, Samuel B Stephens Journal: Diabetes. 2025 Nov 1;74(11):1992-2007 Abstract: Type 1 diabetes (T1D) is caused by the selective autoimmune ablation of pancreatic β-cells. Emerging evidence reveals […]
Article: Long COVID trajectories in the prospectively followed RECOVER-Adult US cohort Authors: Tanayott Thaweethai, Sarah E Donohue, Jeffrey N Martin, Mady Hornig, Jarrod M Mosier, Daniel J Shinnick, Hassan Ashktorab, Ornina Atieh, Andra Blomkalns, Hassan Brim, Yu Chen, Melissa M Cortez, Nathan B Erdmann, Valerie Flaherman, Paul Goepfert, Jason D Goldman, Naomi M Hamburg, Jenny […]
Article: Theratyping as a tool to guide clinical decision-making in patients with suspected cystic fibrosis and variants currently ineligible for CFTR modulator therapy Authors: Ryan M Gannon, Brittany A Wright, Brandon A Bettis, Mary E Teresi, Anthony J Fischer, Rebecca L Weiner, Tahuanty Peña, Douglas B Hornick, Ian M Thornell, Tayyab Rehman, Alejandro A Pezzulo […]
Article: PRMT5 Inhibition Hits a Nerve (Sheath Tumor): A Targeted Strategy for MPNSTs Authors: Alexa P Sheehan, Akshaya Warrier, Rebecca D Dodd Journal: Clin Cancer Res. 2025 Nov 14;31(22):4620-4622 Abstract: Protein arginine methyltransferase 5 inhibitors represent a promising therapeutic approach for multiple cancers, but their clinical development is hindered by toxicity to normal cells. Synthetic […]
Article: A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults Authors: Patricia Winokur, Theresa E Hegmann, Hana M El Sahly, Evan J Anderson; DMID 15-0038 Study Group Journal: J Infect Dis. 2025 Nov 28:jiaf571. doi: 10.1093/infdis/jiaf571. Online ahead of print Abstract: This study of […]
Article: Overlooked and Underdiagnosed: Cardiac Sarcoidosis and Unexplained Ventricular Tachycardia and Fibrillation Authors: Aaron A Sifuentes, Ghazaleh Goldar, Usamah M ElBakkush, Kaushik Gokul, Mohammed Mhanna, Peter Farjo, Paari Dominic Journal: JACC Adv. 2025 Nov;4(11 Pt 1):102246 Abstract: Background: Cardiac sarcoidosis (CS) often manifests as unexplained ventricular tachycardia (VT) and ventricular fibrillation (VF) but remains significantly […]
Article: The Evolution, Current Landscape, and Future Prospects of Oncolytic Virotherapy in Melanoma: Talimogene Laherparepvec and Beyond Authors: John Smestad, John Rieth, Douglas Laux, Mohammed Milhem Journal: Cells. 2025 Oct 17;14(20):1620. doi: 10.3390/cells14201620. Abstract: Oncolytic viruses represent an emerging class of therapeutic agents that have the potential to transform the care of patients with melanoma. […]
Article: Characterization of Serotype-Specific Dengue Virus T-Cell Inhibition Authors: Jinhua Xiang, James H McLinden, Qing Chang, Micaela Fosdick, Hillel Haim, Alexander Ploss, Wesley Hottel, Nirjal Bhattarai, Tomokazu Tamura, Jiayu Zhang, Jon C D Houtman, Jack T Stapleton Journal: J Infect Dis. 2025 Nov 14;232(5):1228-1238. doi: 10.1093/infdis/jiaf241 Abstract: Background: Dengue virus serotype 2 and 3 (DENV-2 […]
Article: Clinical progress note: Phenobarbital in the treatment of alcohol withdrawal syndrome Authors: Thad E Abrams, Matthew V Ronan Journal: J Hosp Med. 2025 Oct;20(10):1094-1098 Abstract: Alcohol withdrawal syndrome (AWS) is a common condition experienced by hospitalized patients. Practice patterns have evolved over time to include the use of phenobarbital, a barbiturate, as an adjunct […]
Article: Integrated approaches to reduce alcohol use in people with liver disease: a scoping review and quantitative analysis Authors: Andrea N Weber, Marcus Osman, Laurel Smeins, Sahil Chawla, Mary M Thomas, Stephan Arndt, Nicholas L Bormann Journal: Alcohol and Alcoholism, Volume 60, Issue 6, November 2025 Abstract: Aims: Alcohol-associated liver disease (ALD) and alcohol use […]