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Hyperammonemic Encephalopathy in Fibrolamellar Hepatocellular Carcinoma: A Case of Rapid Neurologic Recovery Following Cytoreductive Surgery

Article: Hyperammonemic Encephalopathy in Fibrolamellar Hepatocellular Carcinoma: A Case of Rapid Neurologic Recovery Following Cytoreductive Surgery Authors: Robert Schoeneich, Udhayvir S Grewal, Tanner J Simonson, Bohae R Lee, Rishi R Patel, Andrew J Vegel, Mark W Karwal, Carlos H F Chan, Naomi H Fei Journal: J Clin Exp Hepatol. 2025 Nov-Dec;15(6):102629 Excerpt: Fibrolamellar hepatocellular carcinoma […]

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Neutrophils are key modulators of sex differences in LPS-induced shock in mice

Article: Neutrophils are key modulators of sex differences in LPS-induced shock in mice Authors: Prabuddha Sarkar, Lalita Mazgaeen, Saurabh Saini, Neelam Gautam, Austin Paden, Hanna Paton, Parker Boevers, Julia Duvall, Corey Parlet, Jennifer Bermick, Prajwal Gurung Journal: Blood Vessel Thromb Hemost. 2025 Aug 25;2(4):100104 Abstract: Lipopolysaccharide (LPS) exposure in mice induces robust morbidity and mortality, […]

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Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine

Article: Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine Authors: Dao-Fu Dai, Nastaran Daneshgar, Kaihao Wang, Pei-Ing Liang, Dustin Bosch, Chad Grueter Journal: NPJ Aging. 2025 Nov 25;11(1):9 Abstract: We investigate the effects of α-Klotho, an anti-aging hormone, on cell proliferation across three tissues with varying […]

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Proinflammatory Cytokines Mediate Pancreatic β-Cell-Specific Alterations to Golgi Integrity via iNOS-Dependent Mitochondrial Inhibition

Article: Proinflammatory Cytokines Mediate Pancreatic β-Cell-Specific Alterations to Golgi Integrity via iNOS-Dependent Mitochondrial Inhibition Authors: Sandra E Blom, Palin R Narsian, Riley M Behan-Bush, James A Ankrum, Ling Yang, Samuel B Stephens Journal: Diabetes. 2025 Nov 1;74(11):1992-2007 Abstract: Type 1 diabetes (T1D) is caused by the selective autoimmune ablation of pancreatic β-cells. Emerging evidence reveals […]

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Long COVID trajectories in the prospectively followed RECOVER-Adult US cohort

Article: Long COVID trajectories in the prospectively followed RECOVER-Adult US cohort Authors: Tanayott Thaweethai, Sarah E Donohue, Jeffrey N Martin, Mady Hornig, Jarrod M Mosier, Daniel J Shinnick, Hassan Ashktorab, Ornina Atieh, Andra Blomkalns, Hassan Brim, Yu Chen, Melissa M Cortez, Nathan B Erdmann, Valerie Flaherman, Paul Goepfert, Jason D Goldman, Naomi M Hamburg, Jenny […]

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Theratyping as a tool to guide clinical decision-making in patients with suspected cystic fibrosis and variants currently ineligible for CFTR modulator therapy

Article: Theratyping as a tool to guide clinical decision-making in patients with suspected cystic fibrosis and variants currently ineligible for CFTR modulator therapy Authors: Ryan M Gannon, Brittany A Wright, Brandon A Bettis, Mary E Teresi, Anthony J Fischer, Rebecca L Weiner, Tahuanty Peña, Douglas B Hornick, Ian M Thornell, Tayyab Rehman, Alejandro A Pezzulo […]

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PRMT5 Inhibition Hits a Nerve (Sheath Tumor): A Targeted Strategy for MPNSTs

Article: PRMT5 Inhibition Hits a Nerve (Sheath Tumor): A Targeted Strategy for MPNSTs Authors: Alexa P Sheehan, Akshaya Warrier, Rebecca D Dodd Journal: Clin Cancer Res. 2025 Nov 14;31(22):4620-4622 Abstract: Protein arginine methyltransferase 5 inhibitors represent a promising therapeutic approach for multiple cancers, but their clinical development is hindered by toxicity to normal cells. Synthetic […]

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A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults

Article: A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults Authors: Patricia Winokur, Theresa E Hegmann, Hana M El Sahly, Evan J Anderson; DMID 15-0038 Study Group Journal: J Infect Dis. 2025 Nov 28:jiaf571. doi: 10.1093/infdis/jiaf571. Online ahead of print Abstract: This study of […]

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Overlooked and Underdiagnosed: Cardiac Sarcoidosis and Unexplained Ventricular Tachycardia and Fibrillation

Article: Overlooked and Underdiagnosed: Cardiac Sarcoidosis and Unexplained Ventricular Tachycardia and Fibrillation Authors: Aaron A Sifuentes, Ghazaleh Goldar, Usamah M ElBakkush, Kaushik Gokul, Mohammed Mhanna, Peter Farjo, Paari Dominic Journal: JACC Adv. 2025 Nov;4(11 Pt 1):102246 Abstract: Background: Cardiac sarcoidosis (CS) often manifests as unexplained ventricular tachycardia (VT) and ventricular fibrillation (VF) but remains significantly […]

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The Evolution, Current Landscape, and Future Prospects of Oncolytic Virotherapy in Melanoma: Talimogene Laherparepvec and Beyond

Article: The Evolution, Current Landscape, and Future Prospects of Oncolytic Virotherapy in Melanoma: Talimogene Laherparepvec and Beyond Authors: John Smestad, John Rieth, Douglas Laux, Mohammed Milhem Journal: Cells. 2025 Oct 17;14(20):1620. doi: 10.3390/cells14201620. Abstract: Oncolytic viruses represent an emerging class of therapeutic agents that have the potential to transform the care of patients with melanoma. […]